MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease

The pathogenesis of Parkinson's disease remains unclear that there is no cure for Parkinson's disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson's disease. Here, we demonstrate that miR-9-5p inhibits the dopaminerg...

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Autores principales: Xiao, Zhenyong, Yan, Zhenxing, Sun, Xiang, Zhu, Zhiyuan, Wang, Baoyan, Gao, Mengqi, Lu, Fengfei, Liu, Jian, Zong, Zhitao, Zhang, Hongbo, Guo, Yanwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060974/
https://www.ncbi.nlm.nih.gov/pubmed/35509839
http://dx.doi.org/10.1155/2022/9173514
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author Xiao, Zhenyong
Yan, Zhenxing
Sun, Xiang
Zhu, Zhiyuan
Wang, Baoyan
Gao, Mengqi
Lu, Fengfei
Liu, Jian
Zong, Zhitao
Zhang, Hongbo
Guo, Yanwu
author_facet Xiao, Zhenyong
Yan, Zhenxing
Sun, Xiang
Zhu, Zhiyuan
Wang, Baoyan
Gao, Mengqi
Lu, Fengfei
Liu, Jian
Zong, Zhitao
Zhang, Hongbo
Guo, Yanwu
author_sort Xiao, Zhenyong
collection PubMed
description The pathogenesis of Parkinson's disease remains unclear that there is no cure for Parkinson's disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson's disease. Here, we demonstrate that miR-9-5p inhibits the dopaminergic neuron apoptosis via the regulation of β-catenin signaling which directly targets SCRIB, a tumor suppressor gene. Besides, miR-9-5p improved the motor function of mice with Parkinson's disease. The results of this study suggest that miR-9-5p might be a potential therapeutic target against Parkinson's disease.
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spelling pubmed-90609742022-05-03 MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease Xiao, Zhenyong Yan, Zhenxing Sun, Xiang Zhu, Zhiyuan Wang, Baoyan Gao, Mengqi Lu, Fengfei Liu, Jian Zong, Zhitao Zhang, Hongbo Guo, Yanwu Oxid Med Cell Longev Research Article The pathogenesis of Parkinson's disease remains unclear that there is no cure for Parkinson's disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson's disease. Here, we demonstrate that miR-9-5p inhibits the dopaminergic neuron apoptosis via the regulation of β-catenin signaling which directly targets SCRIB, a tumor suppressor gene. Besides, miR-9-5p improved the motor function of mice with Parkinson's disease. The results of this study suggest that miR-9-5p might be a potential therapeutic target against Parkinson's disease. Hindawi 2022-04-25 /pmc/articles/PMC9060974/ /pubmed/35509839 http://dx.doi.org/10.1155/2022/9173514 Text en Copyright © 2022 Zhenyong Xiao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiao, Zhenyong
Yan, Zhenxing
Sun, Xiang
Zhu, Zhiyuan
Wang, Baoyan
Gao, Mengqi
Lu, Fengfei
Liu, Jian
Zong, Zhitao
Zhang, Hongbo
Guo, Yanwu
MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease
title MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease
title_full MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease
title_fullStr MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease
title_full_unstemmed MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease
title_short MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease
title_sort mir-9-5p inhibits the mmp(+)-induced neuron apoptosis through regulating scrib/β-catenin signaling in parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060974/
https://www.ncbi.nlm.nih.gov/pubmed/35509839
http://dx.doi.org/10.1155/2022/9173514
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