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Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker
Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. However, the emergence of drug resistance has brought d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061055/ https://www.ncbi.nlm.nih.gov/pubmed/35510041 http://dx.doi.org/10.1155/2022/3051907 |
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author | Zhang, Yaoting Kadasah, Sultan Xie, Jiaheng Gu, Dongsheng |
author_facet | Zhang, Yaoting Kadasah, Sultan Xie, Jiaheng Gu, Dongsheng |
author_sort | Zhang, Yaoting |
collection | PubMed |
description | Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. However, the emergence of drug resistance has brought difficulties to clinical treatment, and new immune checkpoint research is imminent. The hypoxia-adenosine pathway, in which CD73 encoded by the NT5E gene is a key enzyme for adenosine production, has been identified as an immune checkpoint of great potential. Therefore, NT5E may play an important role in HNSCC. We performed a detailed bioinformatics analysis of NT5E in HNSCC, and the results showed that the overexpression of NT5E in HNSCC was associated with poor prognosis. Our further investigation of the coexpression pattern of HNSCC could provide a reference for drug resistance and immunotherapy studies. |
format | Online Article Text |
id | pubmed-9061055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-90610552022-05-03 Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker Zhang, Yaoting Kadasah, Sultan Xie, Jiaheng Gu, Dongsheng Appl Bionics Biomech Research Article Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. However, the emergence of drug resistance has brought difficulties to clinical treatment, and new immune checkpoint research is imminent. The hypoxia-adenosine pathway, in which CD73 encoded by the NT5E gene is a key enzyme for adenosine production, has been identified as an immune checkpoint of great potential. Therefore, NT5E may play an important role in HNSCC. We performed a detailed bioinformatics analysis of NT5E in HNSCC, and the results showed that the overexpression of NT5E in HNSCC was associated with poor prognosis. Our further investigation of the coexpression pattern of HNSCC could provide a reference for drug resistance and immunotherapy studies. Hindawi 2022-04-25 /pmc/articles/PMC9061055/ /pubmed/35510041 http://dx.doi.org/10.1155/2022/3051907 Text en Copyright © 2022 Yaoting Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Yaoting Kadasah, Sultan Xie, Jiaheng Gu, Dongsheng Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
title | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
title_full | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
title_fullStr | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
title_full_unstemmed | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
title_short | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
title_sort | head and neck squamous cell carcinoma: nt5e could be a prognostic biomarker |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061055/ https://www.ncbi.nlm.nih.gov/pubmed/35510041 http://dx.doi.org/10.1155/2022/3051907 |
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