One-pot synthesis and property study on thieno[3,2-b]furan compounds

Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C–O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and react...

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Detalles Bibliográficos
Autores principales: Ma, Weimin, Huang, Jiawei, Li, Chao, Jiang, Yueren, Li, Baolin, Qi, Ting, Zhu, Xiaozhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061063/
https://www.ncbi.nlm.nih.gov/pubmed/35519975
http://dx.doi.org/10.1039/c9ra00796b
Descripción
Sumario:Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C–O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh(3))(4) and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, K(3)PO(4)·3H(2)O as the base and tert-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates.

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