One-pot synthesis and property study on thieno[3,2-b]furan compounds

Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C–O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and react...

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Autores principales: Ma, Weimin, Huang, Jiawei, Li, Chao, Jiang, Yueren, Li, Baolin, Qi, Ting, Zhu, Xiaozhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061063/
https://www.ncbi.nlm.nih.gov/pubmed/35519975
http://dx.doi.org/10.1039/c9ra00796b
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author Ma, Weimin
Huang, Jiawei
Li, Chao
Jiang, Yueren
Li, Baolin
Qi, Ting
Zhu, Xiaozhang
author_facet Ma, Weimin
Huang, Jiawei
Li, Chao
Jiang, Yueren
Li, Baolin
Qi, Ting
Zhu, Xiaozhang
author_sort Ma, Weimin
collection PubMed
description Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C–O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh(3))(4) and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, K(3)PO(4)·3H(2)O as the base and tert-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates.
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spelling pubmed-90610632022-05-04 One-pot synthesis and property study on thieno[3,2-b]furan compounds Ma, Weimin Huang, Jiawei Li, Chao Jiang, Yueren Li, Baolin Qi, Ting Zhu, Xiaozhang RSC Adv Chemistry Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C–O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh(3))(4) and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, K(3)PO(4)·3H(2)O as the base and tert-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates. The Royal Society of Chemistry 2019-03-01 /pmc/articles/PMC9061063/ /pubmed/35519975 http://dx.doi.org/10.1039/c9ra00796b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ma, Weimin
Huang, Jiawei
Li, Chao
Jiang, Yueren
Li, Baolin
Qi, Ting
Zhu, Xiaozhang
One-pot synthesis and property study on thieno[3,2-b]furan compounds
title One-pot synthesis and property study on thieno[3,2-b]furan compounds
title_full One-pot synthesis and property study on thieno[3,2-b]furan compounds
title_fullStr One-pot synthesis and property study on thieno[3,2-b]furan compounds
title_full_unstemmed One-pot synthesis and property study on thieno[3,2-b]furan compounds
title_short One-pot synthesis and property study on thieno[3,2-b]furan compounds
title_sort one-pot synthesis and property study on thieno[3,2-b]furan compounds
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061063/
https://www.ncbi.nlm.nih.gov/pubmed/35519975
http://dx.doi.org/10.1039/c9ra00796b
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