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Design, synthesis and properties investigation of N(α)-acylation lysine based derivatives
Amino acid-based compounds have attracted attention as environmentally friendly bio-based materials. Our group has recently developed a novel family of N(α)-acylation lysine based derivatives. We introduced long chain acyl groups at the N(α) position selectively by a new synthetic route that avoided...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061198/ https://www.ncbi.nlm.nih.gov/pubmed/35519941 http://dx.doi.org/10.1039/c9ra00213h |
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author | Shi, Ting-Ting Fang, Zheng Zeng, Wen-Bo Yang, Zhao He, Wei Guo, Kai |
author_facet | Shi, Ting-Ting Fang, Zheng Zeng, Wen-Bo Yang, Zhao He, Wei Guo, Kai |
author_sort | Shi, Ting-Ting |
collection | PubMed |
description | Amino acid-based compounds have attracted attention as environmentally friendly bio-based materials. Our group has recently developed a novel family of N(α)-acylation lysine based derivatives. We introduced long chain acyl groups at the N(α) position selectively by a new synthetic route that avoided the process of amino protection and deprotection. Sodium N(α)-octanamide lysine (C8), sodium N(α)-capramide lysine (C10) and sodium N(α)-lauramide lysine (C12) can self-assemble into vesicles spontaneously. As a result, not only do they have potential in drug delivery system but also they may be used as bio-based surfactants applied in cosmetics and other industries. |
format | Online Article Text |
id | pubmed-9061198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90611982022-05-04 Design, synthesis and properties investigation of N(α)-acylation lysine based derivatives Shi, Ting-Ting Fang, Zheng Zeng, Wen-Bo Yang, Zhao He, Wei Guo, Kai RSC Adv Chemistry Amino acid-based compounds have attracted attention as environmentally friendly bio-based materials. Our group has recently developed a novel family of N(α)-acylation lysine based derivatives. We introduced long chain acyl groups at the N(α) position selectively by a new synthetic route that avoided the process of amino protection and deprotection. Sodium N(α)-octanamide lysine (C8), sodium N(α)-capramide lysine (C10) and sodium N(α)-lauramide lysine (C12) can self-assemble into vesicles spontaneously. As a result, not only do they have potential in drug delivery system but also they may be used as bio-based surfactants applied in cosmetics and other industries. The Royal Society of Chemistry 2019-03-06 /pmc/articles/PMC9061198/ /pubmed/35519941 http://dx.doi.org/10.1039/c9ra00213h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Shi, Ting-Ting Fang, Zheng Zeng, Wen-Bo Yang, Zhao He, Wei Guo, Kai Design, synthesis and properties investigation of N(α)-acylation lysine based derivatives |
title | Design, synthesis and properties investigation of N(α)-acylation lysine based derivatives |
title_full | Design, synthesis and properties investigation of N(α)-acylation lysine based derivatives |
title_fullStr | Design, synthesis and properties investigation of N(α)-acylation lysine based derivatives |
title_full_unstemmed | Design, synthesis and properties investigation of N(α)-acylation lysine based derivatives |
title_short | Design, synthesis and properties investigation of N(α)-acylation lysine based derivatives |
title_sort | design, synthesis and properties investigation of n(α)-acylation lysine based derivatives |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061198/ https://www.ncbi.nlm.nih.gov/pubmed/35519941 http://dx.doi.org/10.1039/c9ra00213h |
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