Continuous-flow synthesis of 3,5-disubstituted pyrazoles via sequential alkyne homocoupling and Cope-type hydroamination

A flow chemistry-based approach is presented for the synthesis of 3,5-disubstituted pyrazoles via sequential copper-mediated alkyne homocoupling and Cope-type hydroamination of the intermediary 1,3-diynes in the presence of hydrazine as nucleophilic reaction partner. The proposed multistep methodolo...

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Detalles Bibliográficos
Autores principales: Ötvös, Sándor B., Georgiádes, Ádám, Ozsvár, Dániel, Fülöp, Ferenc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061249/
https://www.ncbi.nlm.nih.gov/pubmed/35518676
http://dx.doi.org/10.1039/c9ra01590f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061249/
https://www.ncbi.nlm.nih.gov/pubmed/35518676
http://dx.doi.org/10.1039/c9ra01590f

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