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Covid-19 vaccine (covishield) heralding Moyamoya angiopathy()()()

INDRODUCTION: Thrombotic complications leading to cerebrovascular events occuring in conjunction with Covid-19 vaccination though rare, is well-documented. Moyamoya Angiopathy is a progressive intracranial vasculopathy leading to recurrent strokes. CASE PRESENTATION: We present two index cases of yo...

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Autores principales: Das, Shambaditya, Kanti Ray, Biman, Pandit, Alak, Dutta, Ajitava, Bhat, Saumen, Bhattacharyya, Dwaipayan, Prava Chakraborty, Arka, Agrawal, Raju, Dubey, Souvik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061582/
http://dx.doi.org/10.1016/j.nerep.2022.100100
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author Das, Shambaditya
Kanti Ray, Biman
Pandit, Alak
Dutta, Ajitava
Bhat, Saumen
Bhattacharyya, Dwaipayan
Prava Chakraborty, Arka
Agrawal, Raju
Dubey, Souvik
author_facet Das, Shambaditya
Kanti Ray, Biman
Pandit, Alak
Dutta, Ajitava
Bhat, Saumen
Bhattacharyya, Dwaipayan
Prava Chakraborty, Arka
Agrawal, Raju
Dubey, Souvik
author_sort Das, Shambaditya
collection PubMed
description INDRODUCTION: Thrombotic complications leading to cerebrovascular events occuring in conjunction with Covid-19 vaccination though rare, is well-documented. Moyamoya Angiopathy is a progressive intracranial vasculopathy leading to recurrent strokes. CASE PRESENTATION: We present two index cases of young patient presenting with stroke and TIA following Covid-19 vaccination (COVISHIELD) leading to unmasking of Moyamoya Angiopathy. CONCLUSION: Arterial stroke following Covid-19 vaccination is documented, but uncommon. However, in the background of a vasculopathy, it may not be so rare. Moyamoya Angiopathy has been closely studied in the model of inflammatory pathophysiology in genetically predisposed patients leading to progressive vaso-occlusive disease. Few reports of Covid-19 infection potentiating Moyamoya Angiopathy symptoms are also documented. Thus, as an extrapolation of the inflammatory etiopathogenesis of Moyamoya Angiopathy, Covid-19 vaccination can similarly affect the Moyamoya symptomatology. These two index cases open new lines of enquiry regarding the interplay of Covid-19 vaccination and neurological destabilization in patients with underlying vasculopathy of inflammatory pathophysiology.
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spelling pubmed-90615822022-05-03 Covid-19 vaccine (covishield) heralding Moyamoya angiopathy()()() Das, Shambaditya Kanti Ray, Biman Pandit, Alak Dutta, Ajitava Bhat, Saumen Bhattacharyya, Dwaipayan Prava Chakraborty, Arka Agrawal, Raju Dubey, Souvik Neuroimmunology Reports Article INDRODUCTION: Thrombotic complications leading to cerebrovascular events occuring in conjunction with Covid-19 vaccination though rare, is well-documented. Moyamoya Angiopathy is a progressive intracranial vasculopathy leading to recurrent strokes. CASE PRESENTATION: We present two index cases of young patient presenting with stroke and TIA following Covid-19 vaccination (COVISHIELD) leading to unmasking of Moyamoya Angiopathy. CONCLUSION: Arterial stroke following Covid-19 vaccination is documented, but uncommon. However, in the background of a vasculopathy, it may not be so rare. Moyamoya Angiopathy has been closely studied in the model of inflammatory pathophysiology in genetically predisposed patients leading to progressive vaso-occlusive disease. Few reports of Covid-19 infection potentiating Moyamoya Angiopathy symptoms are also documented. Thus, as an extrapolation of the inflammatory etiopathogenesis of Moyamoya Angiopathy, Covid-19 vaccination can similarly affect the Moyamoya symptomatology. These two index cases open new lines of enquiry regarding the interplay of Covid-19 vaccination and neurological destabilization in patients with underlying vasculopathy of inflammatory pathophysiology. The Authors. Published by Elsevier B.V. 2022 2022-05-03 /pmc/articles/PMC9061582/ http://dx.doi.org/10.1016/j.nerep.2022.100100 Text en © 2022 The Authors. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Das, Shambaditya
Kanti Ray, Biman
Pandit, Alak
Dutta, Ajitava
Bhat, Saumen
Bhattacharyya, Dwaipayan
Prava Chakraborty, Arka
Agrawal, Raju
Dubey, Souvik
Covid-19 vaccine (covishield) heralding Moyamoya angiopathy()()()
title Covid-19 vaccine (covishield) heralding Moyamoya angiopathy()()()
title_full Covid-19 vaccine (covishield) heralding Moyamoya angiopathy()()()
title_fullStr Covid-19 vaccine (covishield) heralding Moyamoya angiopathy()()()
title_full_unstemmed Covid-19 vaccine (covishield) heralding Moyamoya angiopathy()()()
title_short Covid-19 vaccine (covishield) heralding Moyamoya angiopathy()()()
title_sort covid-19 vaccine (covishield) heralding moyamoya angiopathy()()()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061582/
http://dx.doi.org/10.1016/j.nerep.2022.100100
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