Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a major risk factor for heart failure and is associated with the development of life-threatening cardiac arrhythmias. Using a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model harbouring a mutation in cardiac troponin T (R173W), we a...

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Detalles Bibliográficos
Autores principales: Jung, Philipp, Seibertz, Fitzwilliam, Fakuade, Funsho E., Ignatyeva, Nadezda, Sampathkumar, Shrivatsan, Ritter, Melanie, Li, Housen, Mason, Fleur E., Ebert, Antje, Voigt, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061684/
https://www.ncbi.nlm.nih.gov/pubmed/35499658
http://dx.doi.org/10.1007/s00395-022-00912-z

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