Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases

N6-methyladenosine (m(6)A) is a key area in Epigenetics and has been increasingly focused these years. In the m(6)A process, readers recognize the m(6)A modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important m(6)A reader...

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Autores principales: Yan, Huaqing, Zhang, Liqi, Cui, Xiaobo, Zheng, Sinian, Li, Rubing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061745/
https://www.ncbi.nlm.nih.gov/pubmed/35501308
http://dx.doi.org/10.1038/s41420-022-01040-2
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author Yan, Huaqing
Zhang, Liqi
Cui, Xiaobo
Zheng, Sinian
Li, Rubing
author_facet Yan, Huaqing
Zhang, Liqi
Cui, Xiaobo
Zheng, Sinian
Li, Rubing
author_sort Yan, Huaqing
collection PubMed
description N6-methyladenosine (m(6)A) is a key area in Epigenetics and has been increasingly focused these years. In the m(6)A process, readers recognize the m(6)A modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important m(6)A reader, plays a key role in many biological functions and disease progression, especially cancers. Here we summarized the current mechanisms of YTHDC1 in biological functions and diseases and offered guidance for future researches to provide potential strategy for clinical diagnose and therapy.
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spelling pubmed-90617452022-05-04 Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases Yan, Huaqing Zhang, Liqi Cui, Xiaobo Zheng, Sinian Li, Rubing Cell Death Discov Review Article N6-methyladenosine (m(6)A) is a key area in Epigenetics and has been increasingly focused these years. In the m(6)A process, readers recognize the m(6)A modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important m(6)A reader, plays a key role in many biological functions and disease progression, especially cancers. Here we summarized the current mechanisms of YTHDC1 in biological functions and diseases and offered guidance for future researches to provide potential strategy for clinical diagnose and therapy. Nature Publishing Group UK 2022-05-02 /pmc/articles/PMC9061745/ /pubmed/35501308 http://dx.doi.org/10.1038/s41420-022-01040-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Yan, Huaqing
Zhang, Liqi
Cui, Xiaobo
Zheng, Sinian
Li, Rubing
Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases
title Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases
title_full Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases
title_fullStr Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases
title_full_unstemmed Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases
title_short Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases
title_sort roles and mechanisms of the m(6)a reader ythdc1 in biological processes and diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061745/
https://www.ncbi.nlm.nih.gov/pubmed/35501308
http://dx.doi.org/10.1038/s41420-022-01040-2
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