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Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex

GPR88 is an orphan class A G-protein-coupled receptor that is highly expressed in the striatum and regulates diverse brain and behavioral functions. Here we present cryo-EM structures of the human GPR88-Gi1 signaling complex with or without a synthetic agonist (1R, 2R)-2-PCCA. We show that (1R, 2R)-...

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Detalles Bibliográficos
Autores principales:	Chen, Geng, Xu, Jun, Inoue, Asuka, Schmidt, Maximilian F., Bai, Chen, Lu, Qiuyuan, Gmeiner, Peter, Liu, Zheng, Du, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061749/ https://www.ncbi.nlm.nih.gov/pubmed/35501348 http://dx.doi.org/10.1038/s41467-022-30081-5

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