Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology

We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged l-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = μs to m...

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Detalles Bibliográficos
Autores principales: Zaitsev-Doyle, John J., Puchert, Anke, Pfeifer, Yannik, Yan, Hao, Yorke, Briony A., Müller-Werkmeister, Henrike M., Uetrecht, Charlotte, Rehbein, Julia, Huse, Nils, Pearson, Arwen R., Sans, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061760/
https://www.ncbi.nlm.nih.gov/pubmed/35518684
http://dx.doi.org/10.1039/c9ra00968j
Descripción
Sumario:We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged l-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = μs to ms) and quantum yields (φ = 0.05 to 0.14).

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