Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology

We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged l-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = μs to m...

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Autores principales: Zaitsev-Doyle, John J., Puchert, Anke, Pfeifer, Yannik, Yan, Hao, Yorke, Briony A., Müller-Werkmeister, Henrike M., Uetrecht, Charlotte, Rehbein, Julia, Huse, Nils, Pearson, Arwen R., Sans, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061760/
https://www.ncbi.nlm.nih.gov/pubmed/35518684
http://dx.doi.org/10.1039/c9ra00968j
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author Zaitsev-Doyle, John J.
Puchert, Anke
Pfeifer, Yannik
Yan, Hao
Yorke, Briony A.
Müller-Werkmeister, Henrike M.
Uetrecht, Charlotte
Rehbein, Julia
Huse, Nils
Pearson, Arwen R.
Sans, Marta
author_facet Zaitsev-Doyle, John J.
Puchert, Anke
Pfeifer, Yannik
Yan, Hao
Yorke, Briony A.
Müller-Werkmeister, Henrike M.
Uetrecht, Charlotte
Rehbein, Julia
Huse, Nils
Pearson, Arwen R.
Sans, Marta
author_sort Zaitsev-Doyle, John J.
collection PubMed
description We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged l-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = μs to ms) and quantum yields (φ = 0.05 to 0.14).
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spelling pubmed-90617602022-05-04 Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology Zaitsev-Doyle, John J. Puchert, Anke Pfeifer, Yannik Yan, Hao Yorke, Briony A. Müller-Werkmeister, Henrike M. Uetrecht, Charlotte Rehbein, Julia Huse, Nils Pearson, Arwen R. Sans, Marta RSC Adv Chemistry We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged l-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = μs to ms) and quantum yields (φ = 0.05 to 0.14). The Royal Society of Chemistry 2019-03-15 /pmc/articles/PMC9061760/ /pubmed/35518684 http://dx.doi.org/10.1039/c9ra00968j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zaitsev-Doyle, John J.
Puchert, Anke
Pfeifer, Yannik
Yan, Hao
Yorke, Briony A.
Müller-Werkmeister, Henrike M.
Uetrecht, Charlotte
Rehbein, Julia
Huse, Nils
Pearson, Arwen R.
Sans, Marta
Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology
title Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology
title_full Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology
title_fullStr Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology
title_full_unstemmed Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology
title_short Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology
title_sort synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061760/
https://www.ncbi.nlm.nih.gov/pubmed/35518684
http://dx.doi.org/10.1039/c9ra00968j
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