Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program

Deficiency of the immune checkpoint lymphocyte activation gene-3 (LAG3) protein is significantly associated with both elevated HDL-cholesterol (HDL-C) and myocardial infarction risk. We determined the association of genetic variants within ±500 kb of LAG3 with plasma LAG3 and defined LAG3-associated...

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Detalles Bibliográficos
Autores principales: Manichaikul, Ani, Lin, Honghuang, Kang, Chansuk, Yang, Chaojie, Rich, Stephen S., Taylor, Kent D., Guo, Xiuqing, Rotter, Jerome I., Craig Johnson, W., Cornell, Elaine, Tracy, Russell P., Peter Durda, J., Liu, Yongmei, Vasan, Ramachandran S., Adrienne Cupples, L., Gerszten, Robert E., Clish, Clary B., Jain, Deepti, Conomos, Matthew P., Blackwell, Thomas, Papanicolaou, George J., Rodriguez, Annabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061762/
https://www.ncbi.nlm.nih.gov/pubmed/35501457
http://dx.doi.org/10.1038/s42003-022-03304-0

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