Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

An excitatory neuron subset in the spinal dorsal horn (SDH) that expresses gastrin-releasing peptide receptors (GRPR) is critical for pruriceptive transmission. Here, we show that glutamatergic excitatory inputs onto GRPR(+) neurons are facilitated in mouse models of chronic itch. In these models, n...

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Detalles Bibliográficos
Autores principales: Kanehisa, Kensho, Koga, Keisuke, Maejima, Sho, Shiraishi, Yuto, Asai, Konatsu, Shiratori-Hayashi, Miho, Xiao, Mei-Fang, Sakamoto, Hirotaka, Worley, Paul F., Tsuda, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061767/
https://www.ncbi.nlm.nih.gov/pubmed/35501343
http://dx.doi.org/10.1038/s41467-022-30089-x

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