Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the human neural tissue is poorly understood. Here, we derive neural progenitor cells, neurons, and brain organoids from skin fibroblast...

Descripción completa

Detalles Bibliográficos
Autores principales: Papes, Fabio, Camargo, Antonio P., de Souza, Janaina S., Carvalho, Vinicius M. A., Szeto, Ryan A., LaMontagne, Erin, Teixeira, José R., Avansini, Simoni H., Sánchez-Sánchez, Sandra M., Nakahara, Thiago S., Santo, Carolina N., Wu, Wei, Yao, Hang, Araújo, Barbara M. P., Velho, Paulo E. N. F., Haddad, Gabriel G., Muotri, Alysson R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061776/
https://www.ncbi.nlm.nih.gov/pubmed/35501322
http://dx.doi.org/10.1038/s41467-022-29942-w

Ejemplares similares

Ejemplares similares