Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers

A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain as a spacer between the two pharmacophores and piperidine as the secondary amine component on the i...

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Autores principales: Rani, Anu, Viljoen, Albertus, Johansen, Matt D., Kremer, Laurent, Kumar, Vipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061829/
https://www.ncbi.nlm.nih.gov/pubmed/35518673
http://dx.doi.org/10.1039/c8ra10532d
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author Rani, Anu
Viljoen, Albertus
Johansen, Matt D.
Kremer, Laurent
Kumar, Vipan
author_facet Rani, Anu
Viljoen, Albertus
Johansen, Matt D.
Kremer, Laurent
Kumar, Vipan
author_sort Rani, Anu
collection PubMed
description A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain as a spacer between the two pharmacophores and piperidine as the secondary amine component on the isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds, exhibiting a minimum inhibitory concentration (MIC(99)) of 6.25 μg mL(−1) against Mycobacterium tuberculosis.
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spelling pubmed-90618292022-05-04 Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers Rani, Anu Viljoen, Albertus Johansen, Matt D. Kremer, Laurent Kumar, Vipan RSC Adv Chemistry A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain as a spacer between the two pharmacophores and piperidine as the secondary amine component on the isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds, exhibiting a minimum inhibitory concentration (MIC(99)) of 6.25 μg mL(−1) against Mycobacterium tuberculosis. The Royal Society of Chemistry 2019-03-13 /pmc/articles/PMC9061829/ /pubmed/35518673 http://dx.doi.org/10.1039/c8ra10532d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Rani, Anu
Viljoen, Albertus
Johansen, Matt D.
Kremer, Laurent
Kumar, Vipan
Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
title Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
title_full Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
title_fullStr Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
title_full_unstemmed Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
title_short Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
title_sort synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061829/
https://www.ncbi.nlm.nih.gov/pubmed/35518673
http://dx.doi.org/10.1039/c8ra10532d
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