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Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin

Thyroid hormones are essential regulators of metabolism, development, and growth. They are formed from pairs of iodinated tyrosine residues within the precursor thyroglobulin (TG), a 660-kDa homodimer of the thyroid gland, by an oxidative coupling reaction. Tyrosine pairs that give rise to thyroid h...

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Detalles Bibliográficos
Autores principales:	Marechal, Nils, Serrano, Banyuhay P., Zhang, Xinyan, Weitz, Charles J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061844/ https://www.ncbi.nlm.nih.gov/pubmed/35501346 http://dx.doi.org/10.1038/s41467-022-30082-4

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