Rare and misincorporated DNA N(6)-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells

The entity of DNA N(6)-methyladenine (6mA) in mammals remains elusive and subsequently its roles in diseases are poorly understood. Here we exploited a bacterial DNA contamination-free and ultrasensitive UHPLC-MS/MS assay to reassess DNA 6mA in human glioblastomas and unveiled that DNA 6mA (~0.08 pp...

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Detalles Bibliográficos
Autores principales: Lyu, Cong, Niu, Yamei, Lai, Weiyi, Wang, Yu, Wang, Yaning, Dai, Peibin, Ma, Chunhui, Chen, Shaokun, Li, Yao, Jiang, Guibin, Liang, Zhiyong, Ma, Wenbin, Gao, Zhengliang, Tong, Wei-Min, Wang, Hailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061847/
https://www.ncbi.nlm.nih.gov/pubmed/35501312
http://dx.doi.org/10.1038/s41421-022-00399-x

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