Cargando…
Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex
Grid cells in entorhinal cortex (EC) encode an individual’s location in space and rely on environmental cues and self-motion cues derived from the individual’s body. Body-derived signals are also primary signals for the sense of self and based on integrated sensorimotor signals (proprioceptive, tact...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061856/ https://www.ncbi.nlm.nih.gov/pubmed/35501331 http://dx.doi.org/10.1038/s42003-022-03361-5 |
_version_ | 1784698810086195200 |
---|---|
author | Moon, Hyuk-June Gauthier, Baptiste Park, Hyeong-Dong Faivre, Nathan Blanke, Olaf |
author_facet | Moon, Hyuk-June Gauthier, Baptiste Park, Hyeong-Dong Faivre, Nathan Blanke, Olaf |
author_sort | Moon, Hyuk-June |
collection | PubMed |
description | Grid cells in entorhinal cortex (EC) encode an individual’s location in space and rely on environmental cues and self-motion cues derived from the individual’s body. Body-derived signals are also primary signals for the sense of self and based on integrated sensorimotor signals (proprioceptive, tactile, visual, motor) that have been shown to enhance self-centered processing. However, it is currently unknown whether such sensorimotor signals that modulate self-centered processing impact grid cells and spatial navigation. Integrating the online manipulation of bodily signals, to modulate self-centered processing, with a spatial navigation task and an fMRI measure to detect grid cell-like representation (GCLR) in humans, we report improved performance in spatial navigation and decreased GCLR in EC. This decrease in entorhinal GCLR was associated with an increase in retrosplenial cortex activity, which was correlated with participants’ navigation performance. These data link self-centered processes during spatial navigation to entorhinal and retrosplenial activity and highlight the role of different bodily factors at play when navigating in VR. |
format | Online Article Text |
id | pubmed-9061856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90618562022-05-04 Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex Moon, Hyuk-June Gauthier, Baptiste Park, Hyeong-Dong Faivre, Nathan Blanke, Olaf Commun Biol Article Grid cells in entorhinal cortex (EC) encode an individual’s location in space and rely on environmental cues and self-motion cues derived from the individual’s body. Body-derived signals are also primary signals for the sense of self and based on integrated sensorimotor signals (proprioceptive, tactile, visual, motor) that have been shown to enhance self-centered processing. However, it is currently unknown whether such sensorimotor signals that modulate self-centered processing impact grid cells and spatial navigation. Integrating the online manipulation of bodily signals, to modulate self-centered processing, with a spatial navigation task and an fMRI measure to detect grid cell-like representation (GCLR) in humans, we report improved performance in spatial navigation and decreased GCLR in EC. This decrease in entorhinal GCLR was associated with an increase in retrosplenial cortex activity, which was correlated with participants’ navigation performance. These data link self-centered processes during spatial navigation to entorhinal and retrosplenial activity and highlight the role of different bodily factors at play when navigating in VR. Nature Publishing Group UK 2022-05-02 /pmc/articles/PMC9061856/ /pubmed/35501331 http://dx.doi.org/10.1038/s42003-022-03361-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Moon, Hyuk-June Gauthier, Baptiste Park, Hyeong-Dong Faivre, Nathan Blanke, Olaf Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex |
title | Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex |
title_full | Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex |
title_fullStr | Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex |
title_full_unstemmed | Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex |
title_short | Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex |
title_sort | sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061856/ https://www.ncbi.nlm.nih.gov/pubmed/35501331 http://dx.doi.org/10.1038/s42003-022-03361-5 |
work_keys_str_mv | AT moonhyukjune senseofselfimpactsspatialnavigationandhexadirectionalcodinginhumanentorhinalcortex AT gauthierbaptiste senseofselfimpactsspatialnavigationandhexadirectionalcodinginhumanentorhinalcortex AT parkhyeongdong senseofselfimpactsspatialnavigationandhexadirectionalcodinginhumanentorhinalcortex AT faivrenathan senseofselfimpactsspatialnavigationandhexadirectionalcodinginhumanentorhinalcortex AT blankeolaf senseofselfimpactsspatialnavigationandhexadirectionalcodinginhumanentorhinalcortex |