Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies

Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases. Nevertheless, very few drugs that target complement proteins have made it...

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Detalles Bibliográficos
Autores principales: Bansal, Loveleena, Nichols, Eva-Maria, Howsmon, Daniel P., Neisen, Jessica, Bessant, Christina M., Cunningham, Fraser, Petit-Frere, Sebastien, Ludbrook, Steve, Damian, Valeriu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061988/
https://www.ncbi.nlm.nih.gov/pubmed/35517827
http://dx.doi.org/10.3389/fphar.2022.855743

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