Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study

Application of adverse outcome pathways (AOP) and integration of quantitative in vitro to in vivo extrapolation (QIVIVE) may support the paradigm shift in toxicity testing to move from apical endpoints in test animals to more mechanism-based in vitro assays. Here, we developed an AOP of proximal tub...

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Detalles Bibliográficos
Autores principales: Jarzina, Sebastian, Di Fiore, Stefano, Ellinger, Bernhard, Reiser, Pia, Frank, Sabrina, Glaser, Markus, Wu, Jiaqing, Taverne, Femke J., Kramer, Nynke I., Mally, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061999/
https://www.ncbi.nlm.nih.gov/pubmed/35516525
http://dx.doi.org/10.3389/ftox.2022.864441

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