A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism

A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO(2) was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO(3)(2−) with a fas...

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Detalles Bibliográficos
Autores principales: Xu, Zhiyang, Chen, Zhen, Liu, Aikun, Ji, Ruixue, Cao, Xiaoqun, Ge, Yanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062019/
https://www.ncbi.nlm.nih.gov/pubmed/35517691
http://dx.doi.org/10.1039/c8ra10328c
Descripción
Sumario:A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO(2) was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO(3)(2−) with a fast response time (3 min) and detection limit of 0.13 μM. Further, it showed low cytotoxicity and was successfully applied to image exogenous mitochondrial SO(2) in cells.

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