A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism

A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO(2) was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO(3)(2−) with a fas...

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Detalles Bibliográficos
Autores principales: Xu, Zhiyang, Chen, Zhen, Liu, Aikun, Ji, Ruixue, Cao, Xiaoqun, Ge, Yanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062019/
https://www.ncbi.nlm.nih.gov/pubmed/35517691
http://dx.doi.org/10.1039/c8ra10328c
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author Xu, Zhiyang
Chen, Zhen
Liu, Aikun
Ji, Ruixue
Cao, Xiaoqun
Ge, Yanqing
author_facet Xu, Zhiyang
Chen, Zhen
Liu, Aikun
Ji, Ruixue
Cao, Xiaoqun
Ge, Yanqing
author_sort Xu, Zhiyang
collection PubMed
description A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO(2) was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO(3)(2−) with a fast response time (3 min) and detection limit of 0.13 μM. Further, it showed low cytotoxicity and was successfully applied to image exogenous mitochondrial SO(2) in cells.
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spelling pubmed-90620192022-05-04 A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism Xu, Zhiyang Chen, Zhen Liu, Aikun Ji, Ruixue Cao, Xiaoqun Ge, Yanqing RSC Adv Chemistry A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO(2) was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO(3)(2−) with a fast response time (3 min) and detection limit of 0.13 μM. Further, it showed low cytotoxicity and was successfully applied to image exogenous mitochondrial SO(2) in cells. The Royal Society of Chemistry 2019-03-18 /pmc/articles/PMC9062019/ /pubmed/35517691 http://dx.doi.org/10.1039/c8ra10328c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Xu, Zhiyang
Chen, Zhen
Liu, Aikun
Ji, Ruixue
Cao, Xiaoqun
Ge, Yanqing
A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism
title A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism
title_full A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism
title_fullStr A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism
title_full_unstemmed A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism
title_short A ratiometric fluorescent probe for detection of exogenous mitochondrial SO(2) based on a FRET mechanism
title_sort ratiometric fluorescent probe for detection of exogenous mitochondrial so(2) based on a fret mechanism
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062019/
https://www.ncbi.nlm.nih.gov/pubmed/35517691
http://dx.doi.org/10.1039/c8ra10328c
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