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The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients

Clinical and experimental studies indicate that the bacterial and fungal gut microbiota modulates immune responses in distant organs including the lungs. Immune dysregulation is associated with severe SARS-CoV-2 infection, and several groups have observed gut bacterial dysbiosis in SARS-CoV-2 infect...

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Autores principales: Reinold, Johanna, Farahpour, Farnoush, Schoerding, Ann-Kathrin, Fehring, Christian, Dolff, Sebastian, Konik, Margarethe, Korth, Johannes, van Baal, Lukas, Buer, Jan, Witzke, Oliver, Westendorf, Astrid M., Kehrmann, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062042/
https://www.ncbi.nlm.nih.gov/pubmed/35521219
http://dx.doi.org/10.3389/fcimb.2022.848650
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author Reinold, Johanna
Farahpour, Farnoush
Schoerding, Ann-Kathrin
Fehring, Christian
Dolff, Sebastian
Konik, Margarethe
Korth, Johannes
van Baal, Lukas
Buer, Jan
Witzke, Oliver
Westendorf, Astrid M.
Kehrmann, Jan
author_facet Reinold, Johanna
Farahpour, Farnoush
Schoerding, Ann-Kathrin
Fehring, Christian
Dolff, Sebastian
Konik, Margarethe
Korth, Johannes
van Baal, Lukas
Buer, Jan
Witzke, Oliver
Westendorf, Astrid M.
Kehrmann, Jan
author_sort Reinold, Johanna
collection PubMed
description Clinical and experimental studies indicate that the bacterial and fungal gut microbiota modulates immune responses in distant organs including the lungs. Immune dysregulation is associated with severe SARS-CoV-2 infection, and several groups have observed gut bacterial dysbiosis in SARS-CoV-2 infected patients, while the fungal gut microbiota remains poorly defined in these patients. We analyzed the fungal gut microbiome from rectal swabs taken prior to anti-infective treatment in 30 SARS-CoV-2 positive (21 non-severe COVID-19 and 9 developing severe/critical COVID-19 patients) and 23 SARS-CoV-2 negative patients by ITS2-sequencing. Pronounced but distinct interconnected fungal communities distinguished SARS-CoV-2 positive and negative patients. Fungal gut microbiota in severe/critical COVID-19 illness was characterized by a reduced diversity, richness and evenness and by an increase of the relative abundance of the Ascomycota phylum compared with non-severe COVID-19 illness. A dominance of a single fungal species with a relative abundance of >75% was a frequent feature in severe/critical COVID-19. The dominating fungal species were highly variable between patients even within the groups. Several fungal taxa were depleted in patients with severe/critical COVID-19.The distinct compositional changes of the fungal gut microbiome in SARS-CoV-2 infection, especially in severe COVID-19 illness, illuminate the necessity of a broader approach to investigate whether the differences in the fungal gut microbiome are consequences of SARS-CoV-2 infection or a predisposing factor for critical illness.
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spelling pubmed-90620422022-05-04 The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients Reinold, Johanna Farahpour, Farnoush Schoerding, Ann-Kathrin Fehring, Christian Dolff, Sebastian Konik, Margarethe Korth, Johannes van Baal, Lukas Buer, Jan Witzke, Oliver Westendorf, Astrid M. Kehrmann, Jan Front Cell Infect Microbiol Cellular and Infection Microbiology Clinical and experimental studies indicate that the bacterial and fungal gut microbiota modulates immune responses in distant organs including the lungs. Immune dysregulation is associated with severe SARS-CoV-2 infection, and several groups have observed gut bacterial dysbiosis in SARS-CoV-2 infected patients, while the fungal gut microbiota remains poorly defined in these patients. We analyzed the fungal gut microbiome from rectal swabs taken prior to anti-infective treatment in 30 SARS-CoV-2 positive (21 non-severe COVID-19 and 9 developing severe/critical COVID-19 patients) and 23 SARS-CoV-2 negative patients by ITS2-sequencing. Pronounced but distinct interconnected fungal communities distinguished SARS-CoV-2 positive and negative patients. Fungal gut microbiota in severe/critical COVID-19 illness was characterized by a reduced diversity, richness and evenness and by an increase of the relative abundance of the Ascomycota phylum compared with non-severe COVID-19 illness. A dominance of a single fungal species with a relative abundance of >75% was a frequent feature in severe/critical COVID-19. The dominating fungal species were highly variable between patients even within the groups. Several fungal taxa were depleted in patients with severe/critical COVID-19.The distinct compositional changes of the fungal gut microbiome in SARS-CoV-2 infection, especially in severe COVID-19 illness, illuminate the necessity of a broader approach to investigate whether the differences in the fungal gut microbiome are consequences of SARS-CoV-2 infection or a predisposing factor for critical illness. Frontiers Media S.A. 2022-04-19 /pmc/articles/PMC9062042/ /pubmed/35521219 http://dx.doi.org/10.3389/fcimb.2022.848650 Text en Copyright © 2022 Reinold, Farahpour, Schoerding, Fehring, Dolff, Konik, Korth, van Baal, Buer, Witzke, Westendorf and Kehrmann https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Reinold, Johanna
Farahpour, Farnoush
Schoerding, Ann-Kathrin
Fehring, Christian
Dolff, Sebastian
Konik, Margarethe
Korth, Johannes
van Baal, Lukas
Buer, Jan
Witzke, Oliver
Westendorf, Astrid M.
Kehrmann, Jan
The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients
title The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients
title_full The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients
title_fullStr The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients
title_full_unstemmed The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients
title_short The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients
title_sort fungal gut microbiome exhibits reduced diversity and increased relative abundance of ascomycota in severe covid-19 illness and distinct interconnected communities in sars-cov-2 positive patients
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062042/
https://www.ncbi.nlm.nih.gov/pubmed/35521219
http://dx.doi.org/10.3389/fcimb.2022.848650
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