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Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays

The human tyrosyl transfer-RNA (tRNA) synthetase (TyrRS), which is well known for its essential aminoacylation function in protein synthesis, has been shown to translocate to the nucleus and protect against DNA damage caused by external stimuli. Small molecules that can fit into the active site pock...

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Detalles Bibliográficos
Autores principales:	Huang, Shenzhen, Wang, Xiang, Lin, Guifeng, Cheng, Jie, Chen, Xiuli, Sun, Weining, Xiang, Rong, Yu, Yamei, Li, Linli, Yang, Shengyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062088/ https://www.ncbi.nlm.nih.gov/pubmed/35517706 http://dx.doi.org/10.1039/c9ra00458k

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