A Stage-Specific OTX2 Regulatory Network and Maturation-Associated Gene Programs Are Inherent Barriers to RPE Neural Competency

The retinal pigment epithelium (RPE) exhibits a diverse range of plasticity across vertebrates and is a potential source of cells for the regeneration of retinal neurons. Embryonic amniotes possess a transitory ability to regenerate neural retina through the reprogramming of RPE cells in an FGF-depe...

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Detalles Bibliográficos
Autores principales: Tangeman, Jared A., Pérez-Estrada, J. Raúl, Van Zeeland, Emily, Liu, Lin, Danciutiu, Alexandra, Grajales-Esquivel, Erika, Smucker, Byran, Liang, Chun, Del Rio-Tsonis, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062105/
https://www.ncbi.nlm.nih.gov/pubmed/35517508
http://dx.doi.org/10.3389/fcell.2022.875155

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