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Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones
A new and efficient one-pot strategy combining catalyst-free synthesis and iodine catalysis has been developed for the synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones. This approach affords products in moderate to high yields (up to 96%) with excellent diastereoselecti...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062170/ https://www.ncbi.nlm.nih.gov/pubmed/35520709 http://dx.doi.org/10.1039/c9ra01665a |
| _version_ | 1784698874805354496 |
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| author | Zheng, Ya-Yun Feng, Kai-Xiang Xia, Ai-Bao Liu, Jie Tang, Cheng-Ke Zhou, Zhan-Yu Xu, Dan-Qian |
| author_facet | Zheng, Ya-Yun Feng, Kai-Xiang Xia, Ai-Bao Liu, Jie Tang, Cheng-Ke Zhou, Zhan-Yu Xu, Dan-Qian |
| author_sort | Zheng, Ya-Yun |
| collection | PubMed |
| description | A new and efficient one-pot strategy combining catalyst-free synthesis and iodine catalysis has been developed for the synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones. This approach affords products in moderate to high yields (up to 96%) with excellent diastereoselectivities (up to >25 : 1 dr). The reaction is simple to carry out and is metal-free. |
| format | Online Article Text |
| id | pubmed-9062170 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90621702022-05-04 Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones Zheng, Ya-Yun Feng, Kai-Xiang Xia, Ai-Bao Liu, Jie Tang, Cheng-Ke Zhou, Zhan-Yu Xu, Dan-Qian RSC Adv Chemistry A new and efficient one-pot strategy combining catalyst-free synthesis and iodine catalysis has been developed for the synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones. This approach affords products in moderate to high yields (up to 96%) with excellent diastereoselectivities (up to >25 : 1 dr). The reaction is simple to carry out and is metal-free. The Royal Society of Chemistry 2019-03-27 /pmc/articles/PMC9062170/ /pubmed/35520709 http://dx.doi.org/10.1039/c9ra01665a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Zheng, Ya-Yun Feng, Kai-Xiang Xia, Ai-Bao Liu, Jie Tang, Cheng-Ke Zhou, Zhan-Yu Xu, Dan-Qian Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones |
| title | Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones |
| title_full | Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones |
| title_fullStr | Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones |
| title_full_unstemmed | Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones |
| title_short | Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones |
| title_sort | merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062170/ https://www.ncbi.nlm.nih.gov/pubmed/35520709 http://dx.doi.org/10.1039/c9ra01665a |
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