Microglia: The Hub of Intercellular Communication in Ischemic Stroke

Communication between microglia and other cells has recently been at the forefront of research in central nervous system (CNS) disease. In this review, we provide an overview of the neuroinflammation mediated by microglia, highlight recent studies of crosstalk between microglia and CNS resident and...

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Autores principales: Zhang, Yunsha, Lian, Lu, Fu, Rong, Liu, Jueling, Shan, Xiaoqian, Jin, Yang, Xu, Shixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062186/
https://www.ncbi.nlm.nih.gov/pubmed/35518646
http://dx.doi.org/10.3389/fncel.2022.889442
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author Zhang, Yunsha
Lian, Lu
Fu, Rong
Liu, Jueling
Shan, Xiaoqian
Jin, Yang
Xu, Shixin
author_facet Zhang, Yunsha
Lian, Lu
Fu, Rong
Liu, Jueling
Shan, Xiaoqian
Jin, Yang
Xu, Shixin
author_sort Zhang, Yunsha
collection PubMed
description Communication between microglia and other cells has recently been at the forefront of research in central nervous system (CNS) disease. In this review, we provide an overview of the neuroinflammation mediated by microglia, highlight recent studies of crosstalk between microglia and CNS resident and infiltrating cells in the context of ischemic stroke (IS), and discuss how these interactions affect the course of IS. The in-depth exploration of microglia-intercellular communication will be beneficial for therapeutic tools development and clinical translation for stroke control.
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spelling pubmed-90621862022-05-04 Microglia: The Hub of Intercellular Communication in Ischemic Stroke Zhang, Yunsha Lian, Lu Fu, Rong Liu, Jueling Shan, Xiaoqian Jin, Yang Xu, Shixin Front Cell Neurosci Cellular Neuroscience Communication between microglia and other cells has recently been at the forefront of research in central nervous system (CNS) disease. In this review, we provide an overview of the neuroinflammation mediated by microglia, highlight recent studies of crosstalk between microglia and CNS resident and infiltrating cells in the context of ischemic stroke (IS), and discuss how these interactions affect the course of IS. The in-depth exploration of microglia-intercellular communication will be beneficial for therapeutic tools development and clinical translation for stroke control. Frontiers Media S.A. 2022-04-18 /pmc/articles/PMC9062186/ /pubmed/35518646 http://dx.doi.org/10.3389/fncel.2022.889442 Text en Copyright © 2022 Zhang, Lian, Fu, Liu, Shan, Jin and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Zhang, Yunsha
Lian, Lu
Fu, Rong
Liu, Jueling
Shan, Xiaoqian
Jin, Yang
Xu, Shixin
Microglia: The Hub of Intercellular Communication in Ischemic Stroke
title Microglia: The Hub of Intercellular Communication in Ischemic Stroke
title_full Microglia: The Hub of Intercellular Communication in Ischemic Stroke
title_fullStr Microglia: The Hub of Intercellular Communication in Ischemic Stroke
title_full_unstemmed Microglia: The Hub of Intercellular Communication in Ischemic Stroke
title_short Microglia: The Hub of Intercellular Communication in Ischemic Stroke
title_sort microglia: the hub of intercellular communication in ischemic stroke
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062186/
https://www.ncbi.nlm.nih.gov/pubmed/35518646
http://dx.doi.org/10.3389/fncel.2022.889442
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AT furong microgliathehubofintercellularcommunicationinischemicstroke
AT liujueling microgliathehubofintercellularcommunicationinischemicstroke
AT shanxiaoqian microgliathehubofintercellularcommunicationinischemicstroke
AT jinyang microgliathehubofintercellularcommunicationinischemicstroke
AT xushixin microgliathehubofintercellularcommunicationinischemicstroke

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