Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction

We report here that C–C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Yage, Wu, Dan, Hernández, Willinton Yesid, Ma, Changru, Su, Huangyang, Ordomsky, Vitaly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062200/
https://www.ncbi.nlm.nih.gov/pubmed/35520721
http://dx.doi.org/10.1039/c8ra08316a
Descripción
Sumario:We report here that C–C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α-carbon atom by an alkyl group of another molecule. Finally, secondary amines and tertiary amines with longer alkyl chains are formed.

Ejemplares similares