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Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction

We report here that C–C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α...

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Autores principales: Zhou, Yage, Wu, Dan, Hernández, Willinton Yesid, Ma, Changru, Su, Huangyang, Ordomsky, Vitaly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062200/
https://www.ncbi.nlm.nih.gov/pubmed/35520721
http://dx.doi.org/10.1039/c8ra08316a
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author Zhou, Yage
Wu, Dan
Hernández, Willinton Yesid
Ma, Changru
Su, Huangyang
Ordomsky, Vitaly
author_facet Zhou, Yage
Wu, Dan
Hernández, Willinton Yesid
Ma, Changru
Su, Huangyang
Ordomsky, Vitaly
author_sort Zhou, Yage
collection PubMed
description We report here that C–C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α-carbon atom by an alkyl group of another molecule. Finally, secondary amines and tertiary amines with longer alkyl chains are formed.
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spelling pubmed-90622002022-05-04 Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction Zhou, Yage Wu, Dan Hernández, Willinton Yesid Ma, Changru Su, Huangyang Ordomsky, Vitaly RSC Adv Chemistry We report here that C–C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α-carbon atom by an alkyl group of another molecule. Finally, secondary amines and tertiary amines with longer alkyl chains are formed. The Royal Society of Chemistry 2019-03-28 /pmc/articles/PMC9062200/ /pubmed/35520721 http://dx.doi.org/10.1039/c8ra08316a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhou, Yage
Wu, Dan
Hernández, Willinton Yesid
Ma, Changru
Su, Huangyang
Ordomsky, Vitaly
Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction
title Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction
title_full Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction
title_fullStr Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction
title_full_unstemmed Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction
title_short Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction
title_sort alkyl coupling in tertiary amines as analog of guerbet condensation reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062200/
https://www.ncbi.nlm.nih.gov/pubmed/35520721
http://dx.doi.org/10.1039/c8ra08316a
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