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Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction
We report here that C–C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062200/ https://www.ncbi.nlm.nih.gov/pubmed/35520721 http://dx.doi.org/10.1039/c8ra08316a |
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author | Zhou, Yage Wu, Dan Hernández, Willinton Yesid Ma, Changru Su, Huangyang Ordomsky, Vitaly |
author_facet | Zhou, Yage Wu, Dan Hernández, Willinton Yesid Ma, Changru Su, Huangyang Ordomsky, Vitaly |
author_sort | Zhou, Yage |
collection | PubMed |
description | We report here that C–C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α-carbon atom by an alkyl group of another molecule. Finally, secondary amines and tertiary amines with longer alkyl chains are formed. |
format | Online Article Text |
id | pubmed-9062200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90622002022-05-04 Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction Zhou, Yage Wu, Dan Hernández, Willinton Yesid Ma, Changru Su, Huangyang Ordomsky, Vitaly RSC Adv Chemistry We report here that C–C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α-carbon atom by an alkyl group of another molecule. Finally, secondary amines and tertiary amines with longer alkyl chains are formed. The Royal Society of Chemistry 2019-03-28 /pmc/articles/PMC9062200/ /pubmed/35520721 http://dx.doi.org/10.1039/c8ra08316a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Zhou, Yage Wu, Dan Hernández, Willinton Yesid Ma, Changru Su, Huangyang Ordomsky, Vitaly Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction |
title | Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction |
title_full | Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction |
title_fullStr | Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction |
title_full_unstemmed | Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction |
title_short | Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction |
title_sort | alkyl coupling in tertiary amines as analog of guerbet condensation reaction |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062200/ https://www.ncbi.nlm.nih.gov/pubmed/35520721 http://dx.doi.org/10.1039/c8ra08316a |
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