Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report

Anti-N-methyl-D-aspartate receptor (NMDAr) antibody encephalitis is an autoimmune disorder characterized by reduced synaptic activity of the NMDAr due to circulating antibodies that target the NR1 subunit. Few cases of anti-NMDAR encephalitis during pregnancy have been described. The permeation of a...

Descripción completa

Detalles Bibliográficos
Autores principales: Dono, Fedele, Evangelista, Giacomo, Consoli, Stefano, Scorrano, Giovanna, Russo, Mirella, di Pietro, Martina, Onofrj, Marco, Sensi, Stefano L., Anzellotti, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062214/
https://www.ncbi.nlm.nih.gov/pubmed/35520953
http://dx.doi.org/10.1016/j.ebr.2022.100535
Descripción
Sumario:Anti-N-methyl-D-aspartate receptor (NMDAr) antibody encephalitis is an autoimmune disorder characterized by reduced synaptic activity of the NMDAr due to circulating antibodies that target the NR1 subunit. Few cases of anti-NMDAR encephalitis during pregnancy have been described. The permeation of anti-NR1 antibodies through the placenta can be instrumental in the development of complications in newborns. We describe a case of a young woman suffering from anti-NMDAR encephalitis during the first trimester of pregnancy and focus on diagnostic and therapeutic management.

Ejemplares similares