Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report

Anti-N-methyl-D-aspartate receptor (NMDAr) antibody encephalitis is an autoimmune disorder characterized by reduced synaptic activity of the NMDAr due to circulating antibodies that target the NR1 subunit. Few cases of anti-NMDAR encephalitis during pregnancy have been described. The permeation of a...

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Autores principales: Dono, Fedele, Evangelista, Giacomo, Consoli, Stefano, Scorrano, Giovanna, Russo, Mirella, di Pietro, Martina, Onofrj, Marco, Sensi, Stefano L., Anzellotti, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062214/
https://www.ncbi.nlm.nih.gov/pubmed/35520953
http://dx.doi.org/10.1016/j.ebr.2022.100535
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author Dono, Fedele
Evangelista, Giacomo
Consoli, Stefano
Scorrano, Giovanna
Russo, Mirella
di Pietro, Martina
Onofrj, Marco
Sensi, Stefano L.
Anzellotti, Francesca
author_facet Dono, Fedele
Evangelista, Giacomo
Consoli, Stefano
Scorrano, Giovanna
Russo, Mirella
di Pietro, Martina
Onofrj, Marco
Sensi, Stefano L.
Anzellotti, Francesca
author_sort Dono, Fedele
collection PubMed
description Anti-N-methyl-D-aspartate receptor (NMDAr) antibody encephalitis is an autoimmune disorder characterized by reduced synaptic activity of the NMDAr due to circulating antibodies that target the NR1 subunit. Few cases of anti-NMDAR encephalitis during pregnancy have been described. The permeation of anti-NR1 antibodies through the placenta can be instrumental in the development of complications in newborns. We describe a case of a young woman suffering from anti-NMDAR encephalitis during the first trimester of pregnancy and focus on diagnostic and therapeutic management.
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spelling pubmed-90622142022-05-04 Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report Dono, Fedele Evangelista, Giacomo Consoli, Stefano Scorrano, Giovanna Russo, Mirella di Pietro, Martina Onofrj, Marco Sensi, Stefano L. Anzellotti, Francesca Epilepsy Behav Rep Case Report Anti-N-methyl-D-aspartate receptor (NMDAr) antibody encephalitis is an autoimmune disorder characterized by reduced synaptic activity of the NMDAr due to circulating antibodies that target the NR1 subunit. Few cases of anti-NMDAR encephalitis during pregnancy have been described. The permeation of anti-NR1 antibodies through the placenta can be instrumental in the development of complications in newborns. We describe a case of a young woman suffering from anti-NMDAR encephalitis during the first trimester of pregnancy and focus on diagnostic and therapeutic management. Elsevier 2022-03-19 /pmc/articles/PMC9062214/ /pubmed/35520953 http://dx.doi.org/10.1016/j.ebr.2022.100535 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Dono, Fedele
Evangelista, Giacomo
Consoli, Stefano
Scorrano, Giovanna
Russo, Mirella
di Pietro, Martina
Onofrj, Marco
Sensi, Stefano L.
Anzellotti, Francesca
Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report
title Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report
title_full Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report
title_fullStr Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report
title_full_unstemmed Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report
title_short Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report
title_sort anti n-methyl-d-aspartate receptor (nmdar) encephalitis during pregnancy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062214/
https://www.ncbi.nlm.nih.gov/pubmed/35520953
http://dx.doi.org/10.1016/j.ebr.2022.100535
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