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Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration and aging
The Escherichia coli dihydrofolate reductase (DHFR) destabilizing domain (DD) serves as a promising approach to conditionally regulate protein abundance in a variety of tissues. To test whether this approach could be effectively applied to a wide variety of aged and disease-related ocular mouse mode...
Autores principales: | Peng, Hui, Ramadurgum, Prerana, Woodard, DaNae R., Daniel, Steffi, Nakahara, Emi, Renwick, Marian, Aredo, Bogale, Datta, Shyamtanu, Chen, Bo, Ufret-Vincenty, Rafael, Hulleman, John D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062244/ https://www.ncbi.nlm.nih.gov/pubmed/35521529 http://dx.doi.org/10.1016/j.isci.2022.104206 |
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