Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells

The unfolded protein response (UPR) is an adaptation mechanism activated to resolve transient accumulation of unfolded/misfolded proteins in the endoplasmic reticulum. Failure to resolve the transient accumulation of such proteins results in UPR-mediated programmed cell death. Loss of tumor suppress...

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Detalles Bibliográficos
Autores principales: Kour, Smit, Rana, Sandeep, Kubica, Sydney P., Kizhake, Smitha, Ahmad, Mudassier, Muñoz-Trujillo, Catalina, Klinkebiel, David, Singh, Sarbjit, Mallareddy, Jayapal Reddy, Chandra, Surabhi, Woods, Nicholas T., Karpf, Adam R., Natarajan, Amarnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062249/
https://www.ncbi.nlm.nih.gov/pubmed/35378132
http://dx.doi.org/10.1016/j.jbc.2022.101890

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