Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate

Synthesis of 5-aminolevulinic acid (5-ALA) was presented with novel bromination of biobased methyl levulinate (ML), followed by ammoniation and hydrolysis. Copper bromide (CuBr(2)) was employed as the bromination reagent with higher selectivity and activity instead of the conventional liquid bromine...

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Detalles Bibliográficos
Autores principales: Zai, Yuxia, Feng, Yunchao, Zeng, Xianhai, Tang, Xing, Sun, Yong, Lin, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062401/
https://www.ncbi.nlm.nih.gov/pubmed/35520939
http://dx.doi.org/10.1039/c9ra01517e
Descripción
Sumario:Synthesis of 5-aminolevulinic acid (5-ALA) was presented with novel bromination of biobased methyl levulinate (ML), followed by ammoniation and hydrolysis. Copper bromide (CuBr(2)) was employed as the bromination reagent with higher selectivity and activity instead of the conventional liquid bromine (Br(2)). 5-ALA was obtained in a high yield (64%) and purity (>95%) by optimum design, which is of great potential in industrialization.

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