Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate

Synthesis of 5-aminolevulinic acid (5-ALA) was presented with novel bromination of biobased methyl levulinate (ML), followed by ammoniation and hydrolysis. Copper bromide (CuBr(2)) was employed as the bromination reagent with higher selectivity and activity instead of the conventional liquid bromine...

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Autores principales: Zai, Yuxia, Feng, Yunchao, Zeng, Xianhai, Tang, Xing, Sun, Yong, Lin, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062401/
https://www.ncbi.nlm.nih.gov/pubmed/35520939
http://dx.doi.org/10.1039/c9ra01517e
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author Zai, Yuxia
Feng, Yunchao
Zeng, Xianhai
Tang, Xing
Sun, Yong
Lin, Lu
author_facet Zai, Yuxia
Feng, Yunchao
Zeng, Xianhai
Tang, Xing
Sun, Yong
Lin, Lu
author_sort Zai, Yuxia
collection PubMed
description Synthesis of 5-aminolevulinic acid (5-ALA) was presented with novel bromination of biobased methyl levulinate (ML), followed by ammoniation and hydrolysis. Copper bromide (CuBr(2)) was employed as the bromination reagent with higher selectivity and activity instead of the conventional liquid bromine (Br(2)). 5-ALA was obtained in a high yield (64%) and purity (>95%) by optimum design, which is of great potential in industrialization.
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spelling pubmed-90624012022-05-04 Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate Zai, Yuxia Feng, Yunchao Zeng, Xianhai Tang, Xing Sun, Yong Lin, Lu RSC Adv Chemistry Synthesis of 5-aminolevulinic acid (5-ALA) was presented with novel bromination of biobased methyl levulinate (ML), followed by ammoniation and hydrolysis. Copper bromide (CuBr(2)) was employed as the bromination reagent with higher selectivity and activity instead of the conventional liquid bromine (Br(2)). 5-ALA was obtained in a high yield (64%) and purity (>95%) by optimum design, which is of great potential in industrialization. The Royal Society of Chemistry 2019-04-01 /pmc/articles/PMC9062401/ /pubmed/35520939 http://dx.doi.org/10.1039/c9ra01517e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zai, Yuxia
Feng, Yunchao
Zeng, Xianhai
Tang, Xing
Sun, Yong
Lin, Lu
Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate
title Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate
title_full Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate
title_fullStr Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate
title_full_unstemmed Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate
title_short Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate
title_sort synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062401/
https://www.ncbi.nlm.nih.gov/pubmed/35520939
http://dx.doi.org/10.1039/c9ra01517e
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