Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group

The nickel(ii)-catalyzed ortho-arylation of unactivated C–H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionall...

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Detalles Bibliográficos
Autores principales: Cong, Zhanqing, Gao, Feng, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062466/
https://www.ncbi.nlm.nih.gov/pubmed/35515296
http://dx.doi.org/10.1039/c9ra00749k
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author Cong, Zhanqing
Gao, Feng
Liu, Hong
author_facet Cong, Zhanqing
Gao, Feng
Liu, Hong
author_sort Cong, Zhanqing
collection PubMed
description The nickel(ii)-catalyzed ortho-arylation of unactivated C–H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionally, the obtained products bearing a biaryl motif and an amino acid represent bioactive molecules with wide bioactivities.
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spelling pubmed-90624662022-05-04 Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group Cong, Zhanqing Gao, Feng Liu, Hong RSC Adv Chemistry The nickel(ii)-catalyzed ortho-arylation of unactivated C–H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionally, the obtained products bearing a biaryl motif and an amino acid represent bioactive molecules with wide bioactivities. The Royal Society of Chemistry 2019-04-08 /pmc/articles/PMC9062466/ /pubmed/35515296 http://dx.doi.org/10.1039/c9ra00749k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Cong, Zhanqing
Gao, Feng
Liu, Hong
Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group
title Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group
title_full Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group
title_fullStr Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group
title_full_unstemmed Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group
title_short Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group
title_sort ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl c–h bonds utilizing amino acids as a directing group
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062466/
https://www.ncbi.nlm.nih.gov/pubmed/35515296
http://dx.doi.org/10.1039/c9ra00749k
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