Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress

AIMS: Visceral hypersensitivity is a major clinic symptom in patients with irritable bowel syndrome (IBS). Anterior cingulate cortex (ACC) is involved in processing the information of pain. Both G protein‐coupled receptor kinase 6 (GRK6) and P2Y purinoceptor 6 (P2Y6) are associated with neuroinflamm...

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Detalles Bibliográficos
Autores principales: Tian, Yuan‐Qing, Li, Jia‐Hui, Li, Yong‐Chang, Xu, Yu‐Cheng, Zhang, Ping‐An, Wang, Qian, Li, Rui, Xu, Guang‐Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062565/
https://www.ncbi.nlm.nih.gov/pubmed/35349212
http://dx.doi.org/10.1111/cns.13827

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