Mycobacterium tuberculosis DosS binds H(2)S through its Fe(3+) heme iron to regulate the DosR dormancy regulon

Mycobacterium tuberculosis (Mtb) senses and responds to host-derived gasotransmitters NO and CO via heme-containing sensor kinases DosS and DosT and the response regulator DosR. Hydrogen sulfide (H(2)S) is an important signaling molecule in mammals, but its role in Mtb physiology is unclear. We have...

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Detalles Bibliográficos
Autores principales: Sevalkar, Ritesh R., Glasgow, Joel N., Pettinati, Martín, Marti, Marcelo A., Reddy, Vineel P., Basu, Swati, Alipour, Elmira, Kim-Shapiro, Daniel B., Estrin, Dario A., Lancaster, Jack R., Steyn, Adrie J.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062744/
https://www.ncbi.nlm.nih.gov/pubmed/35489241
http://dx.doi.org/10.1016/j.redox.2022.102316

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