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Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous clinical manifestations and the pathogenesis of SLE is still unclear. Various omics results have been reported for SLE, but the molecular hallmarks of SLE, especially in patients with different disease activity, us...

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Autores principales: Huang, Xiaolan, Luu, Laurence Don Wai, Jia, Nan, Zhu, Jia, Fu, Jin, Xiao, Fei, Liu, Chunyan, Li, Shengnan, Shu, Gaixiu, Hou, Jun, Kang, Min, Zhang, Dan, Xu, Yingjie, Wang, Yi, Cui, Xiaodai, Lai, Jianming, Li, Jieqiong, Tai, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063006/
https://www.ncbi.nlm.nih.gov/pubmed/35514958
http://dx.doi.org/10.3389/fimmu.2022.833699
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author Huang, Xiaolan
Luu, Laurence Don Wai
Jia, Nan
Zhu, Jia
Fu, Jin
Xiao, Fei
Liu, Chunyan
Li, Shengnan
Shu, Gaixiu
Hou, Jun
Kang, Min
Zhang, Dan
Xu, Yingjie
Wang, Yi
Cui, Xiaodai
Lai, Jianming
Li, Jieqiong
Tai, Jun
author_facet Huang, Xiaolan
Luu, Laurence Don Wai
Jia, Nan
Zhu, Jia
Fu, Jin
Xiao, Fei
Liu, Chunyan
Li, Shengnan
Shu, Gaixiu
Hou, Jun
Kang, Min
Zhang, Dan
Xu, Yingjie
Wang, Yi
Cui, Xiaodai
Lai, Jianming
Li, Jieqiong
Tai, Jun
author_sort Huang, Xiaolan
collection PubMed
description Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous clinical manifestations and the pathogenesis of SLE is still unclear. Various omics results have been reported for SLE, but the molecular hallmarks of SLE, especially in patients with different disease activity, using an integrated multi-omics approach have not been fully investigated. Here, we collected blood samples from 10 healthy controls (HCs) and 40 SLE patients with different clinical activity including inactive (IA), low activity (LA), and high activity (HA). Using an integrative analysis of proteomic, metabolomic and lipidomic profiles, we report the multi-omics landscape for SLE. The molecular changes suggest that both the complement system and the inflammatory response were activated in SLEs and were associated with disease activity. Additionally, activation of the immunoglobulin mediated immune response were observed in the LA stage of the disease, however this immune response was suppressed slightly in the HA stage. Finally, an imbalance in lipid metabolism, especially in sphingolipid metabolism, accompanied with dysregulated apolipoproteins were observed to contribute to the disease activity of SLE. The multi-omics data presented in this study and the characterization of peripheral blood from SLE patients may thus help provide important clues regarding the pathogenesis of SLE.
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spelling pubmed-90630062022-05-04 Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus Huang, Xiaolan Luu, Laurence Don Wai Jia, Nan Zhu, Jia Fu, Jin Xiao, Fei Liu, Chunyan Li, Shengnan Shu, Gaixiu Hou, Jun Kang, Min Zhang, Dan Xu, Yingjie Wang, Yi Cui, Xiaodai Lai, Jianming Li, Jieqiong Tai, Jun Front Immunol Immunology Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous clinical manifestations and the pathogenesis of SLE is still unclear. Various omics results have been reported for SLE, but the molecular hallmarks of SLE, especially in patients with different disease activity, using an integrated multi-omics approach have not been fully investigated. Here, we collected blood samples from 10 healthy controls (HCs) and 40 SLE patients with different clinical activity including inactive (IA), low activity (LA), and high activity (HA). Using an integrative analysis of proteomic, metabolomic and lipidomic profiles, we report the multi-omics landscape for SLE. The molecular changes suggest that both the complement system and the inflammatory response were activated in SLEs and were associated with disease activity. Additionally, activation of the immunoglobulin mediated immune response were observed in the LA stage of the disease, however this immune response was suppressed slightly in the HA stage. Finally, an imbalance in lipid metabolism, especially in sphingolipid metabolism, accompanied with dysregulated apolipoproteins were observed to contribute to the disease activity of SLE. The multi-omics data presented in this study and the characterization of peripheral blood from SLE patients may thus help provide important clues regarding the pathogenesis of SLE. Frontiers Media S.A. 2022-04-19 /pmc/articles/PMC9063006/ /pubmed/35514958 http://dx.doi.org/10.3389/fimmu.2022.833699 Text en Copyright © 2022 Huang, Luu, Jia, Zhu, Fu, Xiao, Liu, Li, Shu, Hou, Kang, Zhang, Xu, Wang, Cui, Lai, Li and Tai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Xiaolan
Luu, Laurence Don Wai
Jia, Nan
Zhu, Jia
Fu, Jin
Xiao, Fei
Liu, Chunyan
Li, Shengnan
Shu, Gaixiu
Hou, Jun
Kang, Min
Zhang, Dan
Xu, Yingjie
Wang, Yi
Cui, Xiaodai
Lai, Jianming
Li, Jieqiong
Tai, Jun
Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus
title Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus
title_full Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus
title_fullStr Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus
title_full_unstemmed Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus
title_short Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus
title_sort multi-platform omics analysis reveals molecular signatures for pathogenesis and activity of systemic lupus erythematosus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063006/
https://www.ncbi.nlm.nih.gov/pubmed/35514958
http://dx.doi.org/10.3389/fimmu.2022.833699
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