Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol

BACKGROUND: A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse. The year-long maintenance phase is essential in relapse prevention. The Thiopurine Enhance...

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Autores principales: Toksvang, Linea Natalie, Als-Nielsen, Bodil, Bacon, Christopher, Bertasiute, Ruta, Duarte, Ximo, Escherich, Gabriele, Helgadottir, Elín Anna, Johannsdottir, Inga Rinvoll, Jónsson, Ólafur G., Kozlowski, Piotr, Langenskjöld, Cecilia, Lepik, Kristi, Niinimäki, Riitta, Overgaard, Ulrik Malthe, Punab, Mari, Räty, Riikka, Segers, Heidi, van der Sluis, Inge, Smith, Owen Patrick, Strullu, Marion, Vaitkevičienė, Goda, Wik, Hilde Skuterud, Heyman, Mats, Schmiegelow, Kjeld
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063225/
https://www.ncbi.nlm.nih.gov/pubmed/35501736
http://dx.doi.org/10.1186/s12885-022-09522-3

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