Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells

Mutations in genes encoding cytochrome c oxidase (mitochondrial complex IV) subunits and assembly factors [e.g., synthesis of cytochrome c oxidase 2 (SCO2)] are linked to severe metabolic syndromes. Notwithstanding that SCO2 is under transcriptional control of tumor suppressor p53, the role of mitoc...

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Detalles Bibliográficos
Autores principales: Uchenunu, Oro, Zhdanov, Alexander V., Hutton, Phillipe, Jovanovic, Predrag, Wang, Ye, Andreev, Dmitry E., Hulea, Laura, Papadopoli, David J., Avizonis, Daina, Baranov, Pavel V., Pollak, Michael N., Papkovsky, Dmitri B., Topisirovic, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063438/
https://www.ncbi.nlm.nih.gov/pubmed/35302710
http://dx.doi.org/10.1002/2211-5463.13398

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