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The dynamics of cell death patterns and regeneration during acute liver injury in mice
Acute liver injury is a serious clinical syndrome with multiple causes and unclear pathological process. Here, CCl(4)‐ and D‐galactosamine/lipopolysaccharide (D‐gal/LPS)‐induced acute liver injury was established to explore the cell death patterns and determine whether or not liver regeneration occu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063440/ https://www.ncbi.nlm.nih.gov/pubmed/35184410 http://dx.doi.org/10.1002/2211-5463.13383 |
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author | Shao, Shuai Zhang, Yu Li, Guantong Yu, Zhenjun Cao, Yingying Zheng, Lina Zhang, Kun Han, Xiaohui Shi, Zhemin Cui, Hongmei Song, Xiaomeng Hong, Wei Han, Tao |
author_facet | Shao, Shuai Zhang, Yu Li, Guantong Yu, Zhenjun Cao, Yingying Zheng, Lina Zhang, Kun Han, Xiaohui Shi, Zhemin Cui, Hongmei Song, Xiaomeng Hong, Wei Han, Tao |
author_sort | Shao, Shuai |
collection | PubMed |
description | Acute liver injury is a serious clinical syndrome with multiple causes and unclear pathological process. Here, CCl(4)‐ and D‐galactosamine/lipopolysaccharide (D‐gal/LPS)‐induced acute liver injury was established to explore the cell death patterns and determine whether or not liver regeneration occurred. In CCl(4)‐induced hepatic injury, three phases, including the early, progressive, and recovery phase, were considered based on alterations of serum transaminases and liver morphology. Moreover, in this model, cytokines exhibited double‐peak fluctuations; apoptosis and pyroptosis persisted throughout all phases; autophagy occurred in the early and the progressive phases; and sufficient and timely hepatocyte regeneration was observed only during the recovery phase. All of these phenomena contribute to mild liver injury and subsequent regeneration. Strikingly, only the early and progressive phases were observed in the D‐gal/LPS model. Slight pyroptosis occurred in the early phase but diminished in the progressive phase, while apoptosis, reduced autophagy, and slight but subsequently diminished regeneration occurred only during the progressive phase, accompanied by a strong cytokine storm, resulting in severe liver injury with high mortality. Taken together, our work reveals variable modes and dynamics of cell death and regeneration, which lead to different consequences for mild and severe acute liver injury, providing a helpful reference for clinical therapy and prognosis. |
format | Online Article Text |
id | pubmed-9063440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90634402022-05-04 The dynamics of cell death patterns and regeneration during acute liver injury in mice Shao, Shuai Zhang, Yu Li, Guantong Yu, Zhenjun Cao, Yingying Zheng, Lina Zhang, Kun Han, Xiaohui Shi, Zhemin Cui, Hongmei Song, Xiaomeng Hong, Wei Han, Tao FEBS Open Bio Research Articles Acute liver injury is a serious clinical syndrome with multiple causes and unclear pathological process. Here, CCl(4)‐ and D‐galactosamine/lipopolysaccharide (D‐gal/LPS)‐induced acute liver injury was established to explore the cell death patterns and determine whether or not liver regeneration occurred. In CCl(4)‐induced hepatic injury, three phases, including the early, progressive, and recovery phase, were considered based on alterations of serum transaminases and liver morphology. Moreover, in this model, cytokines exhibited double‐peak fluctuations; apoptosis and pyroptosis persisted throughout all phases; autophagy occurred in the early and the progressive phases; and sufficient and timely hepatocyte regeneration was observed only during the recovery phase. All of these phenomena contribute to mild liver injury and subsequent regeneration. Strikingly, only the early and progressive phases were observed in the D‐gal/LPS model. Slight pyroptosis occurred in the early phase but diminished in the progressive phase, while apoptosis, reduced autophagy, and slight but subsequently diminished regeneration occurred only during the progressive phase, accompanied by a strong cytokine storm, resulting in severe liver injury with high mortality. Taken together, our work reveals variable modes and dynamics of cell death and regeneration, which lead to different consequences for mild and severe acute liver injury, providing a helpful reference for clinical therapy and prognosis. John Wiley and Sons Inc. 2022-03-05 /pmc/articles/PMC9063440/ /pubmed/35184410 http://dx.doi.org/10.1002/2211-5463.13383 Text en © 2022 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Shao, Shuai Zhang, Yu Li, Guantong Yu, Zhenjun Cao, Yingying Zheng, Lina Zhang, Kun Han, Xiaohui Shi, Zhemin Cui, Hongmei Song, Xiaomeng Hong, Wei Han, Tao The dynamics of cell death patterns and regeneration during acute liver injury in mice |
title | The dynamics of cell death patterns and regeneration during acute liver injury in mice |
title_full | The dynamics of cell death patterns and regeneration during acute liver injury in mice |
title_fullStr | The dynamics of cell death patterns and regeneration during acute liver injury in mice |
title_full_unstemmed | The dynamics of cell death patterns and regeneration during acute liver injury in mice |
title_short | The dynamics of cell death patterns and regeneration during acute liver injury in mice |
title_sort | dynamics of cell death patterns and regeneration during acute liver injury in mice |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063440/ https://www.ncbi.nlm.nih.gov/pubmed/35184410 http://dx.doi.org/10.1002/2211-5463.13383 |
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