Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma

Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial‐mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty acids (FFAs). However, the effect of FFA metabolism...

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Autores principales: Gao, Jie, Ma, Kangjie, Zhang, Li, Li, Tao, Zhao, Baodong, Jiang, Yaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063443/
https://www.ncbi.nlm.nih.gov/pubmed/35032368
http://dx.doi.org/10.1002/2211-5463.13367
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author Gao, Jie
Ma, Kangjie
Zhang, Li
Li, Tao
Zhao, Baodong
Jiang, Yaping
author_facet Gao, Jie
Ma, Kangjie
Zhang, Li
Li, Tao
Zhao, Baodong
Jiang, Yaping
author_sort Gao, Jie
collection PubMed
description Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial‐mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty acids (FFAs). However, the effect of FFA metabolism on autophagy in SACC remains unknown. In this study, we showed that overexpression of paired related homeobox 1 (PRRX1) reduced the number of autophagosomes and decreased the expression of LC3 and Beclin‐1 in SACC patients and SACC‐83 cells in vitro. Moreover, PRRX1‐mediating FFA reprogramming triggered to autophagy via regulating acetyl‐CoA carboxylase 1 (ACC1), leading to invasion and migration in SACC.
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spelling pubmed-90634432022-05-04 Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma Gao, Jie Ma, Kangjie Zhang, Li Li, Tao Zhao, Baodong Jiang, Yaping FEBS Open Bio Research Articles Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial‐mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty acids (FFAs). However, the effect of FFA metabolism on autophagy in SACC remains unknown. In this study, we showed that overexpression of paired related homeobox 1 (PRRX1) reduced the number of autophagosomes and decreased the expression of LC3 and Beclin‐1 in SACC patients and SACC‐83 cells in vitro. Moreover, PRRX1‐mediating FFA reprogramming triggered to autophagy via regulating acetyl‐CoA carboxylase 1 (ACC1), leading to invasion and migration in SACC. John Wiley and Sons Inc. 2022-03-29 /pmc/articles/PMC9063443/ /pubmed/35032368 http://dx.doi.org/10.1002/2211-5463.13367 Text en © 2022 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Gao, Jie
Ma, Kangjie
Zhang, Li
Li, Tao
Zhao, Baodong
Jiang, Yaping
Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
title Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
title_full Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
title_fullStr Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
title_full_unstemmed Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
title_short Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
title_sort paired related homeobox 1 attenuates autophagy via acetyl‐coa carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063443/
https://www.ncbi.nlm.nih.gov/pubmed/35032368
http://dx.doi.org/10.1002/2211-5463.13367
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