FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies

FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor,...

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Autores principales: Shen, Wenyue, Zhou, Quanwei, Peng, Chenxi, Li, Jiaheng, Yuan, Qizhi, Zhu, Hecheng, Zhao, Ming, Jiang, Xingjun, Liu, Weidong, Ren, Caiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063462/
https://www.ncbi.nlm.nih.gov/pubmed/35515121
http://dx.doi.org/10.3389/fonc.2022.880077
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author Shen, Wenyue
Zhou, Quanwei
Peng, Chenxi
Li, Jiaheng
Yuan, Qizhi
Zhu, Hecheng
Zhao, Ming
Jiang, Xingjun
Liu, Weidong
Ren, Caiping
author_facet Shen, Wenyue
Zhou, Quanwei
Peng, Chenxi
Li, Jiaheng
Yuan, Qizhi
Zhu, Hecheng
Zhao, Ming
Jiang, Xingjun
Liu, Weidong
Ren, Caiping
author_sort Shen, Wenyue
collection PubMed
description FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor, inactivation of FBXW7 induces the aberrations of its downstream pathway, resulting in the occurrence of diseases especially tumorigenesis. Here, we decipher the relationship between FBXW7 and the hallmarks of cancer and discuss the underlying mechanisms. Considering the interplay of cancer hallmarks, we propose several prospective strategies for circumventing the deficits of therapeutic resistance and complete cure of cancer patients.
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spelling pubmed-90634622022-05-04 FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies Shen, Wenyue Zhou, Quanwei Peng, Chenxi Li, Jiaheng Yuan, Qizhi Zhu, Hecheng Zhao, Ming Jiang, Xingjun Liu, Weidong Ren, Caiping Front Oncol Oncology FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor, inactivation of FBXW7 induces the aberrations of its downstream pathway, resulting in the occurrence of diseases especially tumorigenesis. Here, we decipher the relationship between FBXW7 and the hallmarks of cancer and discuss the underlying mechanisms. Considering the interplay of cancer hallmarks, we propose several prospective strategies for circumventing the deficits of therapeutic resistance and complete cure of cancer patients. Frontiers Media S.A. 2022-04-19 /pmc/articles/PMC9063462/ /pubmed/35515121 http://dx.doi.org/10.3389/fonc.2022.880077 Text en Copyright © 2022 Shen, Zhou, Peng, Li, Yuan, Zhu, Zhao, Jiang, Liu and Ren https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shen, Wenyue
Zhou, Quanwei
Peng, Chenxi
Li, Jiaheng
Yuan, Qizhi
Zhu, Hecheng
Zhao, Ming
Jiang, Xingjun
Liu, Weidong
Ren, Caiping
FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
title FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
title_full FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
title_fullStr FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
title_full_unstemmed FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
title_short FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
title_sort fbxw7 and the hallmarks of cancer: underlying mechanisms and prospective strategies
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063462/
https://www.ncbi.nlm.nih.gov/pubmed/35515121
http://dx.doi.org/10.3389/fonc.2022.880077
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