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Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage

Neurodegenerative changes in the preclinical stage of Alzheimer’s disease (AD) have recently been the focus of attention because they may present a range of treatment opportunities. A total of 134 elderly volunteers who lived in a local community were investigated and grouped into preclinical and mi...

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Autores principales: Imabayashi, Etsuko, Ishii, Kenji, Toyohara, Jun, Wagatsuma, Kei, Sakata, Muneyuki, Tago, Tetsuro, Ishibashi, Kenji, Kojima, Narumi, Kohda, Noriyuki, Tokumaru, Aya M., Kim, Hunkyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063485/
https://www.ncbi.nlm.nih.gov/pubmed/35517046
http://dx.doi.org/10.3389/fnagi.2022.847094
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author Imabayashi, Etsuko
Ishii, Kenji
Toyohara, Jun
Wagatsuma, Kei
Sakata, Muneyuki
Tago, Tetsuro
Ishibashi, Kenji
Kojima, Narumi
Kohda, Noriyuki
Tokumaru, Aya M.
Kim, Hunkyung
author_facet Imabayashi, Etsuko
Ishii, Kenji
Toyohara, Jun
Wagatsuma, Kei
Sakata, Muneyuki
Tago, Tetsuro
Ishibashi, Kenji
Kojima, Narumi
Kohda, Noriyuki
Tokumaru, Aya M.
Kim, Hunkyung
author_sort Imabayashi, Etsuko
collection PubMed
description Neurodegenerative changes in the preclinical stage of Alzheimer’s disease (AD) have recently been the focus of attention because they may present a range of treatment opportunities. A total of 134 elderly volunteers who lived in a local community were investigated and grouped into preclinical and mild cognitive impairment stages according to the Clinical Dementia Rating test; we also estimated amyloid deposition in the brain using positron emission tomography (PET). A significant interaction between clinical stage and amyloid PET positivity on cerebral atrophy was observed in the bilateral parietal lobe, parahippocampal gyri, hippocampus, fusiform gyrus, and right superior and middle temporal gyri, as previously reported. Early AD-specific voxel of interest (VOI) analysis was also applied and averaged Z-scores in the right, left, bilateral, and right minus left medial temporal early AD specific area were computed. We defined these averaged Z-scores in the right, left, bilateral, and right minus left early AD specific VOI in medial temporal area as R-MedT-Atrophy-score, L-MedT-Atrophy-score, Bil-MedT-Atrophy-score, and R_L-MedT-Atrophy-score, respectively. It revealed that the R_L-MedT-Atrophy-scores were significantly larger in the amyloid-positive than in the amyloid-negative cognitively normal (CN) elderly group, that is, the right medial temporal areas were smaller than left in amyloid positive CN group and these left-right differences were significantly larger in amyloid positive than amyloid negative CN elderly group. The L-MedT-Atrophy-score was slightly larger (p = 0.073), that is, the left medial temporal area was smaller in the amyloid-negative CN group than in the amyloid-positive CN group. Conclusively, the left medial temporal area could be larger in CN participants with amyloid deposition than in those without amyloid deposition. The area under the receiver operating characteristic curve for differentiating amyloid positivity among CN participants using the R_L-MedT-Atrophy-scores was 0.73; the sensitivity and specificity were 0.828 and 0.606, respectively. Although not significant, a negative correlation was observed between the composite cerebral standardized uptake value ratio in amyloid PET images and L-MedT-Atrophy-score in CN group. The left medial temporal volume might become enlarged because of compensatory effects against AD pathology occurring at the beginning of the amyloid deposition.
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spelling pubmed-90634852022-05-04 Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage Imabayashi, Etsuko Ishii, Kenji Toyohara, Jun Wagatsuma, Kei Sakata, Muneyuki Tago, Tetsuro Ishibashi, Kenji Kojima, Narumi Kohda, Noriyuki Tokumaru, Aya M. Kim, Hunkyung Front Aging Neurosci Neuroscience Neurodegenerative changes in the preclinical stage of Alzheimer’s disease (AD) have recently been the focus of attention because they may present a range of treatment opportunities. A total of 134 elderly volunteers who lived in a local community were investigated and grouped into preclinical and mild cognitive impairment stages according to the Clinical Dementia Rating test; we also estimated amyloid deposition in the brain using positron emission tomography (PET). A significant interaction between clinical stage and amyloid PET positivity on cerebral atrophy was observed in the bilateral parietal lobe, parahippocampal gyri, hippocampus, fusiform gyrus, and right superior and middle temporal gyri, as previously reported. Early AD-specific voxel of interest (VOI) analysis was also applied and averaged Z-scores in the right, left, bilateral, and right minus left medial temporal early AD specific area were computed. We defined these averaged Z-scores in the right, left, bilateral, and right minus left early AD specific VOI in medial temporal area as R-MedT-Atrophy-score, L-MedT-Atrophy-score, Bil-MedT-Atrophy-score, and R_L-MedT-Atrophy-score, respectively. It revealed that the R_L-MedT-Atrophy-scores were significantly larger in the amyloid-positive than in the amyloid-negative cognitively normal (CN) elderly group, that is, the right medial temporal areas were smaller than left in amyloid positive CN group and these left-right differences were significantly larger in amyloid positive than amyloid negative CN elderly group. The L-MedT-Atrophy-score was slightly larger (p = 0.073), that is, the left medial temporal area was smaller in the amyloid-negative CN group than in the amyloid-positive CN group. Conclusively, the left medial temporal area could be larger in CN participants with amyloid deposition than in those without amyloid deposition. The area under the receiver operating characteristic curve for differentiating amyloid positivity among CN participants using the R_L-MedT-Atrophy-scores was 0.73; the sensitivity and specificity were 0.828 and 0.606, respectively. Although not significant, a negative correlation was observed between the composite cerebral standardized uptake value ratio in amyloid PET images and L-MedT-Atrophy-score in CN group. The left medial temporal volume might become enlarged because of compensatory effects against AD pathology occurring at the beginning of the amyloid deposition. Frontiers Media S.A. 2022-04-19 /pmc/articles/PMC9063485/ /pubmed/35517046 http://dx.doi.org/10.3389/fnagi.2022.847094 Text en Copyright © 2022 Imabayashi, Ishii, Toyohara, Wagatsuma, Sakata, Tago, Ishibashi, Kojima, Kohda, Tokumaru and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Imabayashi, Etsuko
Ishii, Kenji
Toyohara, Jun
Wagatsuma, Kei
Sakata, Muneyuki
Tago, Tetsuro
Ishibashi, Kenji
Kojima, Narumi
Kohda, Noriyuki
Tokumaru, Aya M.
Kim, Hunkyung
Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage
title Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage
title_full Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage
title_fullStr Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage
title_full_unstemmed Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage
title_short Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage
title_sort possibility of enlargement in left medial temporal areas against cerebral amyloid deposition observed during preclinical stage
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063485/
https://www.ncbi.nlm.nih.gov/pubmed/35517046
http://dx.doi.org/10.3389/fnagi.2022.847094
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