Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia

Four new heptaketides, pseudonectrins A–D (1–4), and four known compounds (5–8) were isolated from cultures of an endophytic fungus Nectria pseudotrichia. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–3 and 4 were assigned by electronic circular dich...

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Detalles Bibliográficos
Autores principales: Fu, Peinan, Zhou, Tingnan, Ren, Fengxia, Zhu, Shuaiming, Zhang, Yang, Zhuang, Wenying, Che, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063488/
https://www.ncbi.nlm.nih.gov/pubmed/35517032
http://dx.doi.org/10.1039/c9ra01787a
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author Fu, Peinan
Zhou, Tingnan
Ren, Fengxia
Zhu, Shuaiming
Zhang, Yang
Zhuang, Wenying
Che, Yongsheng
author_facet Fu, Peinan
Zhou, Tingnan
Ren, Fengxia
Zhu, Shuaiming
Zhang, Yang
Zhuang, Wenying
Che, Yongsheng
author_sort Fu, Peinan
collection PubMed
description Four new heptaketides, pseudonectrins A–D (1–4), and four known compounds (5–8) were isolated from cultures of an endophytic fungus Nectria pseudotrichia. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–3 and 4 were assigned by electronic circular dichroism calculations and the modified Mosher method, respectively. Compound 1–3 showed moderate cytotoxicity, with IC(50) values of 11.6–41.2 μM.
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spelling pubmed-90634882022-05-04 Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia Fu, Peinan Zhou, Tingnan Ren, Fengxia Zhu, Shuaiming Zhang, Yang Zhuang, Wenying Che, Yongsheng RSC Adv Chemistry Four new heptaketides, pseudonectrins A–D (1–4), and four known compounds (5–8) were isolated from cultures of an endophytic fungus Nectria pseudotrichia. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–3 and 4 were assigned by electronic circular dichroism calculations and the modified Mosher method, respectively. Compound 1–3 showed moderate cytotoxicity, with IC(50) values of 11.6–41.2 μM. The Royal Society of Chemistry 2019-04-17 /pmc/articles/PMC9063488/ /pubmed/35517032 http://dx.doi.org/10.1039/c9ra01787a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Fu, Peinan
Zhou, Tingnan
Ren, Fengxia
Zhu, Shuaiming
Zhang, Yang
Zhuang, Wenying
Che, Yongsheng
Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia
title Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia
title_full Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia
title_fullStr Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia
title_full_unstemmed Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia
title_short Pseudonectrins A–D, heptaketides from an endophytic fungus Nectria pseudotrichia
title_sort pseudonectrins a–d, heptaketides from an endophytic fungus nectria pseudotrichia
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063488/
https://www.ncbi.nlm.nih.gov/pubmed/35517032
http://dx.doi.org/10.1039/c9ra01787a
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