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Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma
MoSe(2) is a typical transition-metal dichalcogenide material, and many researches have been focused on using its property of near infrared strong absorption for laser mediated photothermal cancer treatment. However, the anti-canter effect of MoSe(2) and its possible mechanism in renal cell carcinom...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063525/ https://www.ncbi.nlm.nih.gov/pubmed/35520231 http://dx.doi.org/10.1039/c9ra01029g |
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author | Gao, Li Fan, Yi-zeng Zhang, Tao-hong Xu, Hui-qiu Zeng, Xian-ling Hou, Tao Dan, Wei-chao Zeng, Jin An, Rui-fang |
author_facet | Gao, Li Fan, Yi-zeng Zhang, Tao-hong Xu, Hui-qiu Zeng, Xian-ling Hou, Tao Dan, Wei-chao Zeng, Jin An, Rui-fang |
author_sort | Gao, Li |
collection | PubMed |
description | MoSe(2) is a typical transition-metal dichalcogenide material, and many researches have been focused on using its property of near infrared strong absorption for laser mediated photothermal cancer treatment. However, the anti-canter effect of MoSe(2) and its possible mechanism in renal cell carcinoma (RCC) is still unclear. RCC has high incidence of metastasis, which is known as one of the most lethal malignancies in the urological system. This study revealed that the carbon-doped MoSe(2) particles can obviously inhibit proliferation for 786-O and ACHN cells. Meanwhile, the carbon-doped MoSe(2) nanoparticles have little impact on the viability of KH-2 cells in vitro. The mechanism analysis revealed that the carbon-doped MoSe(2) particles have hydrogen bond effect in aqueous solution, and the particle aggregation effect caused the KH-2 cells to have high viability. The carbon-doped MoSe(2) nanoparticles with minimal toxicity may be a potential therapeutic candidate against RCC. |
format | Online Article Text |
id | pubmed-9063525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90635252022-05-04 Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma Gao, Li Fan, Yi-zeng Zhang, Tao-hong Xu, Hui-qiu Zeng, Xian-ling Hou, Tao Dan, Wei-chao Zeng, Jin An, Rui-fang RSC Adv Chemistry MoSe(2) is a typical transition-metal dichalcogenide material, and many researches have been focused on using its property of near infrared strong absorption for laser mediated photothermal cancer treatment. However, the anti-canter effect of MoSe(2) and its possible mechanism in renal cell carcinoma (RCC) is still unclear. RCC has high incidence of metastasis, which is known as one of the most lethal malignancies in the urological system. This study revealed that the carbon-doped MoSe(2) particles can obviously inhibit proliferation for 786-O and ACHN cells. Meanwhile, the carbon-doped MoSe(2) nanoparticles have little impact on the viability of KH-2 cells in vitro. The mechanism analysis revealed that the carbon-doped MoSe(2) particles have hydrogen bond effect in aqueous solution, and the particle aggregation effect caused the KH-2 cells to have high viability. The carbon-doped MoSe(2) nanoparticles with minimal toxicity may be a potential therapeutic candidate against RCC. The Royal Society of Chemistry 2019-04-12 /pmc/articles/PMC9063525/ /pubmed/35520231 http://dx.doi.org/10.1039/c9ra01029g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Gao, Li Fan, Yi-zeng Zhang, Tao-hong Xu, Hui-qiu Zeng, Xian-ling Hou, Tao Dan, Wei-chao Zeng, Jin An, Rui-fang Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma |
title | Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma |
title_full | Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma |
title_fullStr | Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma |
title_full_unstemmed | Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma |
title_short | Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma |
title_sort | biocompatible carbon-doped mose(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063525/ https://www.ncbi.nlm.nih.gov/pubmed/35520231 http://dx.doi.org/10.1039/c9ra01029g |
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