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Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology
A few studies are dealing with the role of fine-needle aspiration cytology in diagnosing osteoarticular tuberculosis (TB). The present study was undertaken to study the cytomorphological features of six cases of osteoarticular TB throughout 1 year, diagnosed by fine-needle aspiration cytology. The P...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Scientific Scholar
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063557/ https://www.ncbi.nlm.nih.gov/pubmed/35510112 http://dx.doi.org/10.25259/Cytojournal_22_2021 |
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author | Dey, Biswajit Nigam, Jitendra Singh Bharti, Jyotsna Naresh Singh, Ashok Nair, Vivek |
author_facet | Dey, Biswajit Nigam, Jitendra Singh Bharti, Jyotsna Naresh Singh, Ashok Nair, Vivek |
author_sort | Dey, Biswajit |
collection | PubMed |
description | A few studies are dealing with the role of fine-needle aspiration cytology in diagnosing osteoarticular tuberculosis (TB). The present study was undertaken to study the cytomorphological features of six cases of osteoarticular TB throughout 1 year, diagnosed by fine-needle aspiration cytology. The Papanicolaou, Giemsa, Ziehl–Neelsen, and periodic acid–Schiff stains were used in each case. The sampled material was also cultured in Lowenstein– Jensen media for Mycobacterium species and polymerase chain reaction assay for Mycobacterium tuberculosis. Histopathological findings were correlated whenever available. There were four male and two female patients. The age of the patients ranged from 15 to 53 years, with a mean age of 37 years. Most cases involved small bones (4/6) and long bones of upper and lower limbs (2/6). Radiologically, the suspected lesions presented as osteolytic lesions, fractures, and joint destruction. The smears showed epithelioid cell granulomas in 5 out of 6 cases (83.3%), multinucleate and Langhans’ giant cells in 3 out of 6 cases (50%), and only necrosis in 1 case (16.7%). Inflammatory cells were seen in the background in 5 out of 6 cases (83.3%). AFB was positive in 3 cases (50%). Culture in Löwenstein–Jensen media, done in three cases, showed growth of M. tuberculosis. PCR showed positivity for M. tuberculosis in all six cases. Fine-needle aspiration cytology is an easy procedure that can be used for the diagnosis of osteoarticular tuberculosis. Cytomorphologically, smears show epithelioid cell granulomas, multinucleated and Langhan’s’ giant cells, and necrosis. |
format | Online Article Text |
id | pubmed-9063557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Scientific Scholar |
record_format | MEDLINE/PubMed |
spelling | pubmed-90635572022-05-03 Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology Dey, Biswajit Nigam, Jitendra Singh Bharti, Jyotsna Naresh Singh, Ashok Nair, Vivek Cytojournal Case Series A few studies are dealing with the role of fine-needle aspiration cytology in diagnosing osteoarticular tuberculosis (TB). The present study was undertaken to study the cytomorphological features of six cases of osteoarticular TB throughout 1 year, diagnosed by fine-needle aspiration cytology. The Papanicolaou, Giemsa, Ziehl–Neelsen, and periodic acid–Schiff stains were used in each case. The sampled material was also cultured in Lowenstein– Jensen media for Mycobacterium species and polymerase chain reaction assay for Mycobacterium tuberculosis. Histopathological findings were correlated whenever available. There were four male and two female patients. The age of the patients ranged from 15 to 53 years, with a mean age of 37 years. Most cases involved small bones (4/6) and long bones of upper and lower limbs (2/6). Radiologically, the suspected lesions presented as osteolytic lesions, fractures, and joint destruction. The smears showed epithelioid cell granulomas in 5 out of 6 cases (83.3%), multinucleate and Langhans’ giant cells in 3 out of 6 cases (50%), and only necrosis in 1 case (16.7%). Inflammatory cells were seen in the background in 5 out of 6 cases (83.3%). AFB was positive in 3 cases (50%). Culture in Löwenstein–Jensen media, done in three cases, showed growth of M. tuberculosis. PCR showed positivity for M. tuberculosis in all six cases. Fine-needle aspiration cytology is an easy procedure that can be used for the diagnosis of osteoarticular tuberculosis. Cytomorphologically, smears show epithelioid cell granulomas, multinucleated and Langhan’s’ giant cells, and necrosis. Scientific Scholar 2022-03-04 /pmc/articles/PMC9063557/ /pubmed/35510112 http://dx.doi.org/10.25259/Cytojournal_22_2021 Text en © 2022 Cytopathology Foundation Inc, Published by Scientific Scholar https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Series Dey, Biswajit Nigam, Jitendra Singh Bharti, Jyotsna Naresh Singh, Ashok Nair, Vivek Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology |
title | Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology |
title_full | Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology |
title_fullStr | Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology |
title_full_unstemmed | Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology |
title_short | Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology |
title_sort | osteoarticular tuberculosis: a series of six cases diagnosed on fine-needle aspiration cytology |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063557/ https://www.ncbi.nlm.nih.gov/pubmed/35510112 http://dx.doi.org/10.25259/Cytojournal_22_2021 |
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