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Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology

A few studies are dealing with the role of fine-needle aspiration cytology in diagnosing osteoarticular tuberculosis (TB). The present study was undertaken to study the cytomorphological features of six cases of osteoarticular TB throughout 1 year, diagnosed by fine-needle aspiration cytology. The P...

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Autores principales: Dey, Biswajit, Nigam, Jitendra Singh, Bharti, Jyotsna Naresh, Singh, Ashok, Nair, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063557/
https://www.ncbi.nlm.nih.gov/pubmed/35510112
http://dx.doi.org/10.25259/Cytojournal_22_2021
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author Dey, Biswajit
Nigam, Jitendra Singh
Bharti, Jyotsna Naresh
Singh, Ashok
Nair, Vivek
author_facet Dey, Biswajit
Nigam, Jitendra Singh
Bharti, Jyotsna Naresh
Singh, Ashok
Nair, Vivek
author_sort Dey, Biswajit
collection PubMed
description A few studies are dealing with the role of fine-needle aspiration cytology in diagnosing osteoarticular tuberculosis (TB). The present study was undertaken to study the cytomorphological features of six cases of osteoarticular TB throughout 1 year, diagnosed by fine-needle aspiration cytology. The Papanicolaou, Giemsa, Ziehl–Neelsen, and periodic acid–Schiff stains were used in each case. The sampled material was also cultured in Lowenstein– Jensen media for Mycobacterium species and polymerase chain reaction assay for Mycobacterium tuberculosis. Histopathological findings were correlated whenever available. There were four male and two female patients. The age of the patients ranged from 15 to 53 years, with a mean age of 37 years. Most cases involved small bones (4/6) and long bones of upper and lower limbs (2/6). Radiologically, the suspected lesions presented as osteolytic lesions, fractures, and joint destruction. The smears showed epithelioid cell granulomas in 5 out of 6 cases (83.3%), multinucleate and Langhans’ giant cells in 3 out of 6 cases (50%), and only necrosis in 1 case (16.7%). Inflammatory cells were seen in the background in 5 out of 6 cases (83.3%). AFB was positive in 3 cases (50%). Culture in Löwenstein–Jensen media, done in three cases, showed growth of M. tuberculosis. PCR showed positivity for M. tuberculosis in all six cases. Fine-needle aspiration cytology is an easy procedure that can be used for the diagnosis of osteoarticular tuberculosis. Cytomorphologically, smears show epithelioid cell granulomas, multinucleated and Langhan’s’ giant cells, and necrosis.
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spelling pubmed-90635572022-05-03 Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology Dey, Biswajit Nigam, Jitendra Singh Bharti, Jyotsna Naresh Singh, Ashok Nair, Vivek Cytojournal Case Series A few studies are dealing with the role of fine-needle aspiration cytology in diagnosing osteoarticular tuberculosis (TB). The present study was undertaken to study the cytomorphological features of six cases of osteoarticular TB throughout 1 year, diagnosed by fine-needle aspiration cytology. The Papanicolaou, Giemsa, Ziehl–Neelsen, and periodic acid–Schiff stains were used in each case. The sampled material was also cultured in Lowenstein– Jensen media for Mycobacterium species and polymerase chain reaction assay for Mycobacterium tuberculosis. Histopathological findings were correlated whenever available. There were four male and two female patients. The age of the patients ranged from 15 to 53 years, with a mean age of 37 years. Most cases involved small bones (4/6) and long bones of upper and lower limbs (2/6). Radiologically, the suspected lesions presented as osteolytic lesions, fractures, and joint destruction. The smears showed epithelioid cell granulomas in 5 out of 6 cases (83.3%), multinucleate and Langhans’ giant cells in 3 out of 6 cases (50%), and only necrosis in 1 case (16.7%). Inflammatory cells were seen in the background in 5 out of 6 cases (83.3%). AFB was positive in 3 cases (50%). Culture in Löwenstein–Jensen media, done in three cases, showed growth of M. tuberculosis. PCR showed positivity for M. tuberculosis in all six cases. Fine-needle aspiration cytology is an easy procedure that can be used for the diagnosis of osteoarticular tuberculosis. Cytomorphologically, smears show epithelioid cell granulomas, multinucleated and Langhan’s’ giant cells, and necrosis. Scientific Scholar 2022-03-04 /pmc/articles/PMC9063557/ /pubmed/35510112 http://dx.doi.org/10.25259/Cytojournal_22_2021 Text en © 2022 Cytopathology Foundation Inc, Published by Scientific Scholar https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Series
Dey, Biswajit
Nigam, Jitendra Singh
Bharti, Jyotsna Naresh
Singh, Ashok
Nair, Vivek
Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology
title Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology
title_full Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology
title_fullStr Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology
title_full_unstemmed Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology
title_short Osteoarticular tuberculosis: A series of six cases diagnosed on fine-needle aspiration cytology
title_sort osteoarticular tuberculosis: a series of six cases diagnosed on fine-needle aspiration cytology
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063557/
https://www.ncbi.nlm.nih.gov/pubmed/35510112
http://dx.doi.org/10.25259/Cytojournal_22_2021
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