Development of self-stratified antibacterial polymers via click chemistry

An azide-modified long perfluorinated tail quaternary ammonium methacrylate compound (M2) was designed and synthesized. The fluorine containing polyurethane (PU-F) with strong antibacterial properties was prepared via click reaction of M2 and a clickable polymer (PU-Al), which exhibited surface segr...

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Autores principales: Peng, Kaimei, Hu, Jianqing, Dai, Xuexin, Yang, Zaibo, Wang, Runping, Tu, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063746/
https://www.ncbi.nlm.nih.gov/pubmed/35520805
http://dx.doi.org/10.1039/c9ra01572h
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author Peng, Kaimei
Hu, Jianqing
Dai, Xuexin
Yang, Zaibo
Wang, Runping
Tu, Weiping
author_facet Peng, Kaimei
Hu, Jianqing
Dai, Xuexin
Yang, Zaibo
Wang, Runping
Tu, Weiping
author_sort Peng, Kaimei
collection PubMed
description An azide-modified long perfluorinated tail quaternary ammonium methacrylate compound (M2) was designed and synthesized. The fluorine containing polyurethane (PU-F) with strong antibacterial properties was prepared via click reaction of M2 and a clickable polymer (PU-Al), which exhibited surface segregation. The PU-F film showed a total kill against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) at an M2 content around 1 wt%. A disk diffusion test confirmed that the ligation efficiency of the antibacterial agents and polymer chains via click chemistry was excellent, and covalent conjugation of the QACs to the polymers prevented leaching.
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spelling pubmed-90637462022-05-04 Development of self-stratified antibacterial polymers via click chemistry Peng, Kaimei Hu, Jianqing Dai, Xuexin Yang, Zaibo Wang, Runping Tu, Weiping RSC Adv Chemistry An azide-modified long perfluorinated tail quaternary ammonium methacrylate compound (M2) was designed and synthesized. The fluorine containing polyurethane (PU-F) with strong antibacterial properties was prepared via click reaction of M2 and a clickable polymer (PU-Al), which exhibited surface segregation. The PU-F film showed a total kill against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) at an M2 content around 1 wt%. A disk diffusion test confirmed that the ligation efficiency of the antibacterial agents and polymer chains via click chemistry was excellent, and covalent conjugation of the QACs to the polymers prevented leaching. The Royal Society of Chemistry 2019-04-30 /pmc/articles/PMC9063746/ /pubmed/35520805 http://dx.doi.org/10.1039/c9ra01572h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Peng, Kaimei
Hu, Jianqing
Dai, Xuexin
Yang, Zaibo
Wang, Runping
Tu, Weiping
Development of self-stratified antibacterial polymers via click chemistry
title Development of self-stratified antibacterial polymers via click chemistry
title_full Development of self-stratified antibacterial polymers via click chemistry
title_fullStr Development of self-stratified antibacterial polymers via click chemistry
title_full_unstemmed Development of self-stratified antibacterial polymers via click chemistry
title_short Development of self-stratified antibacterial polymers via click chemistry
title_sort development of self-stratified antibacterial polymers via click chemistry
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063746/
https://www.ncbi.nlm.nih.gov/pubmed/35520805
http://dx.doi.org/10.1039/c9ra01572h
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AT daixuexin developmentofselfstratifiedantibacterialpolymersviaclickchemistry
AT yangzaibo developmentofselfstratifiedantibacterialpolymersviaclickchemistry
AT wangrunping developmentofselfstratifiedantibacterialpolymersviaclickchemistry
AT tuweiping developmentofselfstratifiedantibacterialpolymersviaclickchemistry

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